Head and Neck Cancer and the PI3K/Akt/mTOR Signaling Network: Novel Molecular Targeted Therapies

2010 ◽  
pp. 407-429
Author(s):  
Panomwat Amornphimoltham ◽  
Vyomesh Patel ◽  
Alfredo Molinolo ◽  
J. Silvio Gutkind
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Targeted Therapies ◽  
Signaling Network ◽  
Mtor Signaling ◽  
Molecular Targeted Therapies

Molecular-Targeted Therapies in Head and Neck Cancer

2012 ◽  
Vol 22 (3) ◽  
pp. 207-213 ◽  
Author(s):  
Shyam D. Rao ◽  
Matthew G. Fury ◽  
David G. Pfister
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Targeted Therapies ◽  
Molecular Targeted Therapies

scholarly journals Protein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancer

2011 ◽  
Vol 14 (6) ◽  
pp. 260-279 ◽  
Author(s):  
Ranee Mehra ◽  
Ilya G. Serebriiskii ◽  
Roland L. Dunbrack ◽  
Matthew K. Robinson ◽  
Barbara Burtness ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Targeted Therapies ◽  
Signaling Network ◽  
Sources Of Resistance ◽  
Erbb Family

Emerging molecular targeted therapies in the treatment of head and neck cancer

2009 ◽  
Vol 14 (2) ◽  
pp. 299-310 ◽  
Author(s):  
Alexandre Bozec ◽  
Frédéric Peyrade ◽  
Jean-Louis Fischel ◽  
Gérard Milano
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Targeted Therapies ◽  
Molecular Targeted Therapies

Promising Newer Molecular-Targeted Therapies in Head and Neck Cancer

Drugs ◽  
2008 ◽  
Vol 68 (12) ◽  
pp. 1609-1619 ◽  
Author(s):  
Lili X Wang ◽  
Mark Agulnik
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Targeted Therapies ◽  
Molecular Targeted Therapies

Molecular Targeted Therapies in Head and Neck Cancer

2011 ◽  
pp. 293-305 ◽  
Author(s):  
Vinai Gondi ◽  
Anne M. Traynor ◽  
Paul M. Harari
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Targeted Therapies ◽  
Molecular Targeted Therapies

Promising New Molecular Targeted Therapies in Head and Neck Cancer

Drugs ◽  
2013 ◽  
Vol 73 (4) ◽  
pp. 315-325 ◽  
Author(s):  
Kelly Dorsey ◽  
Mark Agulnik
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Targeted Therapies ◽  
Molecular Targeted Therapies

scholarly journals Current Insights and Advancements in Head and Neck Cancer: Emerging Biomarkers and Therapeutics with Cues from Single Cell and 3D Model Omics Profiling

2021 ◽  
Vol 11 ◽  
Author(s):  
Yashika Jawa ◽  
Pooja Yadav ◽  
Shruti Gupta ◽  
Sivapar V. Mathan ◽  
Jyoti Pandey ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Tumor Microenvironment ◽  
Head And Neck ◽  
Single Cell ◽  
Neck Cancer ◽  
Targeted Therapies ◽  
Drug Targets ◽  
Final Analysis ◽  
Resistance Pattern ◽  
Molecular Targeted Therapies

Head and neck cancer (HNC) is among the ten leading malignancies worldwide, with India solely contributing one-third of global oral cancer cases. The current focus of all cutting-edge strategies against this global malignancy are directed towards the heterogeneous tumor microenvironment that obstructs most treatment blueprints. Subsequent to the portrayal of established information, the review details the application of single cell technology, organoids and spheroid technology in relevance to head and neck cancer and the tumor microenvironment acknowledging the resistance pattern of the heterogeneous cell population in HNC. Bioinformatic tools are used for study of differentially expressed genes and further omics data analysis. However, these tools have several challenges and limitations when analyzing single-cell gene expression data that are discussed briefly. The review further examines the omics of HNC, through comprehensive analyses of genomics, transcriptomics, proteomics, metabolomics, and epigenomics profiles. Patterns of alterations vary between patients, thus heterogeneity and molecular alterations between patients have driven the clinical significance of molecular targeted therapies. The analyses of potential molecular targets in HNC are discussed with connotation to the alteration of key pathways in HNC followed by a comprehensive study of protein kinases as novel drug targets including its ATPase and additional binding pockets, non-catalytic domains and single residues. We herein review, the therapeutic agents targeting the potential biomarkers in light of new molecular targeted therapies. In the final analysis, this review suggests that the development of improved target-specific personalized therapies can combat HNC’s global plight.

Sign in / Sign up

Export Citation Format

Share Document