International HapMap Project

The mismatch distribution is a good descriptive summary statistic that describes the phenomena of population genetics. This article scanned mismatch distribution on human genome with single nucleotide polymorphism (SNP) data from the International HapMap Project. It is found that the abnormal mismatch distribution could imply some special segments on some chromosomes. One of the segments, on chromosome 8, was proved as an inversion. Other special segments may also imply some special structure on chromosomes, such as duplication. The conjectures of other segments still need further research.

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The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics

Bioinformatics and Biology Insights ◽

10.4137/bbi.s455 ◽

2008 ◽

Vol 2 ◽

pp. BBI.S455 ◽

Cited By ~ 30

Author(s):

Wei Zhang ◽

Mark J. Ratain ◽

M. Eileen Dolan

Keyword(s):

Gene Expression ◽

Complex Traits ◽

Drug Response ◽

Human Populations ◽

International Hapmap Project ◽

Hapmap Project ◽

Phenotypic Data ◽

Human Lymphoblastoid Cell ◽

Human Lymphoblastoid Cell Lines ◽

Japanese Ancestry

The exploration of quantitative variation in complex traits such as gene expression and drug response in human populations has become one of the major priorities for medical genetics. The International HapMap Project provides a key resource of genotypic data on human lymphoblastoid cell lines derived from four major world populations of European, African, Chinese and Japanese ancestry for researchers to associate with various phenotypic data to find genes affecting health, disease and response to drugs. Recent progress in dissecting genetic contribution to natural variation in gene expression within and among human populations and variation in drug response are two examples in which researchers have utilized the HapMap resource. The HapMap Project provides new insights into the human genome and has applicability to pharmacogenomics studies leading to personalized medicine.

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Community Engagement and Informed Consent in the International HapMap Project

Public Health Genomics ◽

10.1159/000101761 ◽

2007 ◽

Vol 10 (3) ◽

pp. 186-198 ◽

Cited By ~ 23

Author(s):

Charles Rotimi ◽

Mark Leppert ◽

Ichiro Matsuda ◽

Changqing Zeng ◽

Houcan Zhang ◽

...

Keyword(s):

Informed Consent ◽

Community Engagement ◽

International Hapmap Project ◽

Hapmap Project

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Integrating ethics and science in the International HapMap Project

Nature Reviews Genetics ◽

10.1038/nrg1351 ◽

2004 ◽

Vol 5 (6) ◽

pp. 467-475 ◽

Cited By ~ 155

Author(s):

Keyword(s):

International Hapmap Project ◽

Hapmap Project ◽

Integrating Ethics

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Genomics and Proteomics Methodologies for Vulnerable Populations Research

Annual Review of Nursing Research ◽

10.1891/0739-6686.25.1.191 ◽

2007 ◽

Vol 25 (1) ◽

pp. 191-217 ◽

Cited By ~ 3

Author(s):

Christine E. Kasper

Keyword(s):

Sample Selection ◽

International Hapmap Project ◽

Population Admixture ◽

Hapmap Project ◽

Nucleotide Polymorphisms ◽

Unique Haplotype ◽

Single Nucleotide ◽

Population Groups ◽

Genomics And Proteomics ◽

Vulnerable Population Groups

This chapter describes common genomic and proteomic methods and their application to the study of vulnerable population groups. The International HapMap project is discussed in relation to unique Haplotype single nucleotide polymorphisms (htSNPs) in population groups. In addition, studies, which have used these methods to investigate aging, ethnic, and racial specific conditions, as well as psychiatric diseases, are reviewed. Advantages and limitations of various genomic and proteomic approaches are discussed in relation to population admixture and sample selection.

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