An Insider’s Response to Racism: Abe Fortas and the Japanese Question during the Asia-Pacific War, 1941–1945

Abe Fortas (1910–1982) has been best known for service during his legal career as an Associate Justice on the Supreme Court of the United States for four years from 1965 to 1969. His supporters have characterized his life as a lawyer who supported and defended the American Civil Rights Movement during the tumultuous periods of the 1950s and 1960s in the United States. However, observers of his career have paid little attention to the fact that Fortas was one of the few American bureaucrats who took the stand in defense of those of Japanese ancestry in the official hearings in the 1980sinvestigating the internment of Japanese Americans during World War ii. Fortas, as undersecretary in the Department of the Interior from 1942 to 1946, had a close relationship to key U.S. policies dealing with people of Japanese ancestry during the Asia-Pacific War, including the establishment of martial law in Hawai‘i and the ending of the Japanese internment. Fortas’s responses to and critiques of U.S. policy regarding the Japanese American question reveal the intertwined dynamics of how white racism developed and challenges against it at the governmental level.

The Impact of ApoE and FOXO3 Genotype on the Risk of Intracerebral Hemorrhage Among American Men of Japanese Ancestry

This study assessed the impact of APOE e2, e4 minor alleles and the FOXO3 longevity-associated genotype (carrier of SNP rs2802292 “G” allele) on 34-year incidence of intracerebral hemorrhage (ICH). Cox regression models were performed to assess the impact of the APOE e2, e4 and FOXO3 G alleles on the incidence of ICH. A total of 6483 participants were eligible for the analyses. 213 participants developed ICH. Cox-regression model showed neither APOE minor allele vs. common genotype (APOE e3/e3: RR 0.89, 95% CI: 0.64-1.22, p=0.46) nor FOXO3 G carrier status (RR 0.97, 95% CI: 0.72-1.29, p=0.82) was associated with incident ICH. Conversely, both hypertension (RR: 1.46, 95% CI: 1.07-2.00, p=0.02) and low cholesterol level (RR: 0.99, 95% CI: 0.99-1.00, p=0.001) were associated with incident ICH. Carriage of APOE e2 or E4 alleles and the FOXO3 G allele do not appear to impact risk of ICH over 34 years in this cohort.

Marginal Citizens: Interracial intimacies and the incarceration of Japanese Canadians, 1942–1949

Following Japan’s 1941 attacks on Hawai’i and Hong Kong, Canada relocated, detained, and exiled citizens and residents of Japanese ancestry. Many interracial families, however, were exempted from this racial project called the internment. The form of the exemption was an administrative permit granted to its holder on the basis of their marital or patrilineal proximity to whiteness. This article analyzes these permits relying on archival research and applying a critical race feminist lens to explore how law was constitutive of race at this moment in Canadian history. I argue that the permits recategorized interracial intimacies towards two racial ends: to differentiate the citizen from the “enemy alien”; and to regulate the interracial family according to patriarchal common law principles. This article nuances received narratives of law as an instrument of racial exclusion by documenting the way in which a new inclusive state measure sustained old exclusions.

Abstract P176: Genes That Increase Human Lifespan By Protecting Against Risk Of Death From Cardiometabolic Diseases

Further to our FOXO3 findings last year, we asked whether other longevity gene variants work by mitigating mortality risk from aging-related diseases. In a longitudinal study, 3,584 American men of Japanese ancestry from the Kuakini Honolulu Heart Program were followed from baseline (Exam 4, 1991-93) until Dec 31, 2019 (1% of men) or death (99%). At baseline, 2,512 subjects had either diabetes (n=1,010), hypertension (n=1,919) or coronary heart disease (CHD; n=738), and 1,072 lacked any cardiometabolic diseases (CMD). DNA samples for genotyping were obtained at baseline. Genotype frequencies of SNPs in MAP3K5 , PIK3R1 , GHR, CTGF , EGFR , FLT1 , SIRT5 and SIRT7 were compared between subjects with and without ageing-related diseases . In subjects with CMD, MAP3K5 rs2076260 longevity-associated genotypes CC and CC + TT were associated with longer lifespan (covariate-adjusted hazard ratio [HR] 1.23 [95% CI: 1.12-1.35, p= 2.5x10 -5 ] in a major allele homozygote model, and 1.22 [95% CI: 1.11-1.33, p= 1.10x10 -5 ] in a heterozygote disadvantage model) compared with CT . For diabetes, hypertension and CHD, HR p -values were 0.019, 0.00048, 0.093, and 0.0024, 0.00040, 0.0014, in each respective genetic model. For PIK3R1 , subjects with cardiovascular disease (CVD) having the longevity-associated genotypes TT / CC of SNP rs7709243 had survival curves similar to those of subjects without a CVD (HR 1.26 [95% CI, 1.14-1.39; p =0.0000043]). In contrast, survival curves of subjects with the CT genotype were significantly lower compared with survival curves of subjects without a CVD ( p =0.0000012 compared with TT / CC , and p =0.0000028 compared with CT ). For GHR SNP rs4130113 , in a heterozygote disadvantage model GG vs longevity-associated AG genotype was associated with reduced mortality risk from hypertension (HR 1.23 [95% CI, 0.94-1.41; p =0.0041]). Men without CVD showed no association of longevity-associated genotype with lifespan. For each gene, men without the disease outlived men with disease ( p < 10 -6 ), but genotype had no effect on lifespan. In conclusion, for MAP3K5 , PIK3R1 and GHR , but not other longevity genes, longevity genotype increases lifespan only in individuals who have CMD, CVD or hypertension, likely by protection against disease-related cellular stress.

Discourse, difference, and dehumanization: justifying the Canadian Japanese internment, 1940-1949

This thesis argues Canadian Members of Parliament used the December 7, 1941 attack on Pearl Harbour as an opportunity to enforce a dominant “us versus them” narrative in order to justify the internment of approximately 22,000 Canadians of Japanese ancestry. National and local newspapers reinforced this narrative through uncritical and biased reporting which negatively framed the Japanese against a more idealized and white “Canadian” identity. Critical discourse analysis was applied on several debates in the House of Commons and news articles in the Daily Colonist and the Globe and Mail between 1940 and 1949, to examine the articulation of social relations – in this case, race and ethnicity – with the goal of uncovering the power relations embedded within the discourse. The findings reveal a clear “us versus them” narrative, whereby Canadians of Japanese ancestry were constructed as “yellow,” “bad,” and “unwanted,” as opposed to white Canadians who were “good” and “loyal.”

Discourse, difference, and dehumanization: justifying the Canadian Japanese internment, 1940-1949

This thesis argues Canadian Members of Parliament used the December 7, 1941 attack on Pearl Harbour as an opportunity to enforce a dominant “us versus them” narrative in order to justify the internment of approximately 22,000 Canadians of Japanese ancestry. National and local newspapers reinforced this narrative through uncritical and biased reporting which negatively framed the Japanese against a more idealized and white “Canadian” identity. Critical discourse analysis was applied on several debates in the House of Commons and news articles in the Daily Colonist and the Globe and Mail between 1940 and 1949, to examine the articulation of social relations – in this case, race and ethnicity – with the goal of uncovering the power relations embedded within the discourse. The findings reveal a clear “us versus them” narrative, whereby Canadians of Japanese ancestry were constructed as “yellow,” “bad,” and “unwanted,” as opposed to white Canadians who were “good” and “loyal.”

Immigration and Democracy in Japan

This chapter examines the politics of immigration in Japan. It begins with an overview of the foreign community in Japan today in comparative perspective, focusing on several competing explanations for why Japan is such an outlier when compared with other advanced industrialized countries. It also examines the new visa categories that were formalized by the 1989 and 2018 revisions to the Immigration Control and Refugee Recognition Act, including visas for those with Japanese ancestry and “trainees” (in the case of the 1989 revision), and visas for laborers who had previously been excluded, including agricultural workers and construction workers (in the case of the 2018 revision). Additionally, this chapter discusses Japan’s famously restrictive refugee admission policy as well as the relationship between public opinion, civil society, and immigration policy in Japan. The chapter concludes with an analysis of the ways that Japan’s immigration policy and policymaking might impact the future of Japan’s democracy. Ultimately, the chapter argues that the way that Japan deals with both the admission and treatment of foreign laborers will help shape the nature of Japan’s democracy going forward.

Outside in: exile at home an algorithmic discrimination system

Outside-in is an installation that utilises machine learning to reflect on systematic discrimination by focusing on the indefinite detention of Mexicans with Japanese heritage concentrated in Morelos during WWII. This algorithmic discrimination system tears apart four classic fiction films continuously within a projection room. The fragments are displaced and classified using machine learning algorithms. The system selects, separates and reassembles the fragments into new orders. It evokes the condition of being robbed of your right to be in the place to which you belong. The citizens detained during WWII were removed from their residence, their belongings were confiscated and they were placed in seclusion solely for having Japanese ancestry. Similarly, at present, data retrieving companies configure low resolution representations of ourselves from the snatched digital debris of our daily life. These pieces are reconfigured into archetypes and meaning is attached to them for massive decision making. We don’t have the right or means to know what these representations look like or what meaning has been attached to such shapes. It is a privilege reserved to the designers of algorithmic processes: they own this right and we the citizens own the consequences. The present article is a case study presenting the creation of Outside in: exile at home as an installation that utilises machine learning and reflects on this kind of systematic discrimination.

Identification of Candidate Genes Associated with Susceptibility to Ovarian Clear Cell Adenocarcinoma Using cis-eQTL Analysis

Ovarian clear cell adenocarcinoma (Ov-CCA) has a higher prevalence in the Japanese ancestry than other populations. The ancestral disparities in Ov-CCA prevalence suggests the presence of Ov-CCA-specific genetic alterations and may provide an opportunity to identify the novel genes associated with Ov-CCA tumorigenesis. Using 94 previously reported genes as the phenotypic trait, we conducted multistep expression quantitative trait loci (eQTL) analysis with the HapMap3 project datasets. Four single-nucleotide polymorphisms (SNPs) (rs4873815, rs12976454, rs11136002, and rs13259097) that had different allele frequencies in the Japanese ancestry and seven genes associated in cis (APBA3, C8orf58, KIAA1967, NAPRT1, RHOBTB2, TNFRSF10B, and ZNF707) were identified. In silico functional annotation analysis and in vitro promoter assay validated the regulatory effect of rs4873815-TT on ZNF707 and rs11136002-TT on TNFRSF10B. Furthermore, ZNF707 was highly expressed in Ov-CCA and had a negative prognostic value in disease recurrence in our sample cohort. This prognostic power was consistently observed in The Cancer Genome Atlas (TCGA) clear cell renal cell carcinoma dataset, suggesting that ZNF707 may have prognostic value in clear cell histology regardless of tissue origin. In conclusion, rs4873815-TT/ZNF707 may have clinical significance in the prognosis and tumorigenesis of Ov-CCA, which may be more relevant to clear cell histology. Besides, this study may underpin the evidence that cis-eQTL analysis based on ancestral disparities can facilitate the discovery of causal genetic alterations in complex diseases, such as cancer.