We developed an in-situ interprofessional simulation program to study system factors to establish a congenital cardiac arrest activation tree and test it using human factors engineering principles. We used the Systems Engineering Initiative for Patient Safety (SEIPS) 2.0 model to understand the structure, processes, and outcomes related to the congenital cardiac arrest activation tree (CCCAT) and discuss the Promoting Excellence and Reflective Learning in Simulation (PEARLS) for systems integration framework for our systems focused debriefing (SFD).