Long-Term Effects of Calcium Channel Blockers on Central and Peripheral Arteries

2014 ◽  
pp. 531-539
Author(s):  
Yoshio Matsui ◽  
Michael F. O’Rourke
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Peripheral Arteries ◽  
Long Term Effects

scholarly journals Effects of calcium antagonists on brain ischemia

2011 ◽  
Vol 64 (5-6) ◽  
pp. 257-261
Author(s):  
Nada Naumovic ◽  
Petar Slankamenac ◽  
Danka Filipovic ◽  
Vesna Ivetic ◽  
Snezana Tomasevic-Todorovic ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Calcium Antagonists ◽  
Barthel Index ◽  
Brain Perfusion ◽  
Functional Independence ◽  
Channel Blockers ◽  
Therapeutic Treatment

Introduction. Stroke is the second leading cause of death in the world and the leading cause of serious, long term disability in adults; about half of those who survive become dependent on others in performing personal activities of daily living. Ischemia disturbs calcium cellular homeostasis, whereas calcium channel blockers re-establish it. This study was aimed at assessing benefits of calcium channel blockers on the outcome of rehabilitation of the patients afflicted by ischemic stroke. Material and Methods. The functional independence was measured by the Barthel index in 90 patients subjected to rehabilitative therapeutic treatment. The functional recovery of patients treated with calcium channel blockers and with other drugs (control) was compared and tested. Results. The analysis of variance (ANOVA) for the 0.5 confidence interval showed that the increases of the Barthel index values were significantly higher in the patients treated with calcium antagonists (p<0.5). Discussion. According to the literature, such an outcome is the result of improved brain blood f low auto-regulation, increased brain perfusion as well as of neuroprotective, antioxidative, platelet antiaggregatory effects of investigated drugs. Conclusion. The calcium channel blockers improved the outcome of rehabilitative therapeutic treatment significantly in the patients afflicted by ischemic stroke.

scholarly journals Comparison of calcium-channel blockers for long-term clinical outcomes in patients with vasospastic angina

2021 ◽  
Vol 36 (1) ◽  
pp. 124-134
Author(s):  
Sung Eun Kim ◽  
Sang-Ho Jo ◽  
Seung Hwan Han ◽  
Kwan Yong Lee ◽  
Sung Ho Her ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Clinical Outcomes ◽  
Calcium Channel Blockers ◽  
Vasospastic Angina ◽  
Channel Blockers

The long-term use of calcium channel blockers and the risk of breast cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1588-1588 ◽  
Author(s):  
Sara V. Soldera ◽  
Nathaniel Bouganim ◽  
Jamil Asselah ◽  
Hui Yin ◽  
Ralph Maroun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers

Systemic Delivery of Calcium Channel Blockers for Hypertension through Transdermal Delivery - A Review

2021 ◽  
Vol 1025 ◽  
pp. 204-208
Author(s):  
Khater Ahmed Saeed AL-Japairai ◽  
Syed Mahmood
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Half Life ◽  
Skin Barrier ◽  
Channel Blockers ◽  
Systemic Delivery ◽  
Delivery Methods ◽  
Significant Public Health ◽  
Public Health Challenge

Hypertension is a significant public health challenge, responsible for a substantial proportion of deaths and disability globally. Calcium Channel Blockers (CCBs) are an essential class for the treatment of hypertension. However, most of CCBs must be taken more than once daily due to their low oral bioavailability and limited half-life, leading to non-compliance in patients. The development of delivery methods for CCBs is an ongoing effort to overcome the issues related to their delivery via their traditional forms. The administration of the drug through the skin for systemic delivery has been recognised as one of the potential routes in hypertension treatment, especially when drugs suffer from low bioavailability, undesirable side effects and short biological half-life following oral administration. The main limitation of transdermal drug delivery is the resistance barrier of skin layers to penetrant molecules. Remarkable research efforts have been made worldwide to minimise the skin barrier and to create transdermal systems of several CCBs via employing skin-enhancing potential. The persistent progress in this field is promising for development the transdermal dosage forms advance technology in the long term and being commercialised sooner rather than later. This review explores the investigations on the viability and applicability of systemic delivery of numerous CCBs through the skin.

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