Complicated and Controversial Considerations Regarding Estrogen Replacement Therapy

1994 ◽  
pp. 395-397
Author(s):  
Nelson B. Watts
Keyword(s):  
Replacement Therapy ◽  
Estrogen Replacement Therapy ◽  
Estrogen Replacement

The Effects of Transdermal Estradiol and Oral Conjugated Estrogens on Haemostasis Variables

1994 ◽  
Vol 71 (04) ◽  
pp. 420-423 ◽  
Author(s):  
Ulla-Beth Kroon ◽  
G Silfverstolpe ◽  
L Tengborn
Keyword(s):  
Replacement Therapy ◽  
Estrogen Replacement Therapy ◽  
Hormone Replacement ◽  
Plasminogen Activator Inhibitor ◽  
Estrogen Replacement ◽  
Transdermal Administration ◽  
Conjugated Estrogens ◽  
Transdermal Estradiol ◽  
Estrogen Administration ◽  
Activator Inhibitor

SummaryThe effects of oral and transdermal administration of estrogen replacement therapy (ERT) have been fairly well investigated regarding lipoprotein and carbohydrate metabolism, while the effects of different modes of estrogen administration on the haemostatic system have been less well studied.To delineate and compare the effects of perorally administered conjugated estrogens (CE) and transdermally administered estradiol (E2) in doses needed for hormone replacement therapy (HRT) on haemostasis parameters, 23 postmenopausal women were engaged in a study with an open cross-over design. The doses compared (0.625 mg CE and 50 μg E2/24h) are the lowest which, with few exceptions, eliminate climacteric symptoms. Both CE and E2 increased factor VII:C, factor VII:Ag, and the prothrombin fragment1+2. The increase in factor VII:Ag, however, was significantly higher after treatment with CE. These changes were all towards a state of hypercoagulability. Furthermore, CE decreased plasminogen activator inhibitor (PAI) and the thrombin-antithrombin complexes (TAT), as well as antithrombin (ATIII).

Effects of Estrogen Replacement Therapy on the Renin-Angiotensin System in Postmenopausal Women

Circulation ◽  
1997 ◽  
Vol 95 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Heribert Schunkert ◽  
A.H. Jan Danser ◽  
Hans-Werner Hense ◽  
Frans H.M. Derkx ◽  
Susanne Ku¨rzinger ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Estrogen Replacement Therapy ◽  
Renin Angiotensin System ◽  
Estrogen Replacement ◽  
Angiotensin System ◽  
Renin Angiotensin

Effects of Estrogen Replacement Therapy on PET Cerebral Blood Flow and Neuropsychological Performance

1998 ◽  
Vol 34 (2) ◽  
pp. 171-182 ◽  
Author(s):  
Susan M. Resnick ◽  
Pauline M. Maki ◽  
Stephanie Golski ◽  
Michael A. Kraut ◽  
Alan B. Zonderman
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Replacement Therapy ◽  
Estrogen Replacement Therapy ◽  
Neuropsychological Performance ◽  
Estrogen Replacement
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