Combined modality treatment with reduced chemotherapy and radiotherapy, and selective splenectomy, in children with Hodgkin’s disease

1985 ◽  
pp. 617-626 ◽  
Author(s):  
G. Schellong ◽  
S. Strauch ◽  
A. K. Waubke ◽  
W. Brandeis ◽  
J. Pawlowsky ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Combined Modality Treatment ◽  
Combined Modality

Massive Mediastinal Involvement in Stage I-II Hodgkin's Disease: Response to Combined Modality Treatment

1992 ◽  
Vol 8 (1-2) ◽  
pp. 81-85 ◽  
Author(s):  
P. L. Zinzani ◽  
P. Mazza ◽  
F. Gherlinzoni ◽  
M. Bocchia ◽  
M. Fiacchini ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Stage I ◽  
Combined Modality Treatment ◽  
Disease Response ◽  
Combined Modality ◽  
Mediastinal Involvement

Meta-analysis of chemotherapy versus combined modality treatment trials in Hodgkin's disease. International Database on Hodgkin's Disease Overview Study Group.

1998 ◽  
Vol 16 (3) ◽  
pp. 818-829 ◽  
Author(s):  
M Loeffler ◽  
O Brosteanu ◽  
D Hasenclever ◽  
M Sextro ◽  
D Assouline ◽  
...  
Keyword(s):  
Overall Survival ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Meta Analysis ◽  
Tumor Control ◽  
Combined Modality Treatment ◽  
Term Survival ◽  
Combined Modality ◽  
Number Of Cycles

DESIGN To perform a meta-analysis of all randomized trials that compared chemotherapy (CT) alone versus combined modality treatment (CT + radiotherapy [RT]) for which individual patient data could be made available. PATIENTS AND METHODS Data on 1,740 patients treated on 14 different trials that included 16 relevant comparisons have been analysed. Eight comparisons were designed to evaluate the benefit of additional RT after the same CT (CT1 v CT1 + RT; additional RT design). Eight comparisons were designed to evaluate whether RT in a combined modality setting can be substituted by CT using either more cycles of the same CT or regimens that contain additional drugs (CT1 + CT2 v CT1 + RT or CT1 v CT2 + RT; parallel RT/CT design). RESULTS Additional RT showed an 11% overall improvement in tumor control rate after 10 years (P = .0001; 95% confidence interval [CI], 4% to 18%). No difference could be detected with respect to overall survival (P = .57; 95% CI, -10% to 4%). In contrast, when combined modality treatment was compared with CT alone in the parallel-design trials, no difference could be detected in tumor control rates (P = .43; 95% CI, -6% to 9%), but overall survival was significantly better after 10 years in the group that did not receive RT (P = .045; 8% difference; 95% CI, 1% to 15%). There were significantly fewer fatal events among patients in continuous complete remission (relative risk [RR], 1.73; 95% CI, 1.17 to 2.53; P = .005) if no RT was given. CONCLUSION Combined modality treatment in patients with advanced-stage Hodgkin's disease overall has a significantly inferior long-term survival outcome than CT alone if CT is given over an appropriate number of cycles. The role of RT in this setting is limited to specific indications.

Treatment of advanced-stage massive mediastinal Hodgkin's disease: the case for combined modality treatment.

1991 ◽  
Vol 9 (2) ◽  
pp. 227-235 ◽  
Author(s):  
D L Longo ◽  
A Russo ◽  
P L Duffey ◽  
S M Hubbard ◽  
E Glatstein ◽  
...  
Keyword(s):  
Overall Survival ◽  
Radiation Therapy ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Disease Free Survival ◽  
Combined Modality Treatment ◽  
Advanced Stage ◽  
Free Survival ◽  
Combined Modality ◽  
Disease Free

In the initial series of 198 patients treated at the National Cancer Institute (NCI) with mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) chemotherapy for Hodgkin's disease, a review of presenting chest radiographs available on 192 of these patients showed 49 patients with mediastinal masses greater than one third the greatest posteroanterior chest diameter. Five patients had stage IIB disease, and 44 had stage III or IV disease. Thirty-five (71%) patients achieved a complete remission with MOPP chemotherapy. Fourteen (40%) of the complete responders relapsed, but four of these achieved durable remissions in response to subsequent therapy. Thirty (61%) patients have died (14 induction failures, nine relapsed patients, seven complete responders in remission). Thus, with a median follow-up of 20 years (range, 15 to 23), the overall survival for the group is 39%, and the disease-free survival for the complete responders is 60%. A subset of 10 patients received mantle radiation therapy after maximal response to MOPP. One of these patients failed to achieve complete remission, but among the nine complete responders only one has relapsed. In contrast, 13 of 26 (50%) patients achieving a complete response to MOPP alone have relapsed (P2 = .0536). Although MOPP alone was not prospectively compared with MOPP plus radiation therapy in the treatment of advanced-stage massive mediastinal Hodgkin's disease in this series, the retrospective analysis shows a nearly significant difference in disease-free survival favoring combined modality treatment. The difference in tumor mortality between MOPP-treated (44%) and combined modality-treated patients (80%) was also nearly significant (P2 = .055). However, overall survival differences between patients treated with MOPP alone and those treated with combined modality therapy were not significantly different (P2 = 0.23) because of the mortality related to late complications of combined modality treatment.

Combined modality treatment of Hodgkin's disease confined to lymph nodes

1979 ◽  
Vol 67 (2) ◽  
pp. 183-193 ◽  
Author(s):  
Peter H. Wiernik ◽  
Joanne Gustafson ◽  
Stephen C. Schimpff ◽  
Charles Diggs
Keyword(s):  
Lymph Nodes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Combined Modality Treatment ◽  
Combined Modality

Combined modality treatment for poor prognosis stages I and II Hodgkin's disease

1996 ◽  
Vol 6 (3) ◽  
pp. 185-195 ◽  
Author(s):  
J.M. Cosset ◽  
C. Fermé ◽  
E.M. Noordijk ◽  
B.M. Dubray ◽  
P. Thirion ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Poor Prognosis ◽  
Hodgkin’S Disease ◽  
Combined Modality Treatment ◽  
Combined Modality
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