2,3,7,8-Tetrachlorodibenzo-P-Dioxin-Induced Weight Loss: A Proposed Mechanism

Human and Environmental Risks of Chlorinated Dioxins and Related Compounds ◽

10.1007/978-1-4613-3599-3_27 ◽

1983 ◽

pp. 405-413 ◽

Cited By ~ 2

Author(s):

Mark D. Seefeld ◽

Richard E. Peterson

Keyword(s):

Weight Loss ◽

Tetrachlorodibenzo P Dioxin

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Hypophagia-Induced Weight Loss in Mice, Rats, and Guinea Pigs Treated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Toxicological Sciences ◽

10.1093/toxsci/5.4.700 ◽

1985 ◽

Vol 5 (4) ◽

pp. 700-712

Author(s):

CHRISTOPHER K. KELLING ◽

BRIAN J. CHRISTIAN ◽

STANLEY L. INHORN ◽

RICHARD E. PETERSON

Keyword(s):

Weight Loss ◽

Guinea Pigs ◽

Tetrachlorodibenzo P Dioxin

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Modulation of rat hepatic microsomal testosterone hydroxylases by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related toxic isostereomers

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y85-253 ◽

1985 ◽

Vol 63 (12) ◽

pp. 1537-1542 ◽

Cited By ~ 13

Author(s):

Barbara Keys ◽

Michelle Hlavinka ◽

Grant Mason ◽

Stephen Safe

Keyword(s):

Weight Loss ◽

Body Weight Loss ◽

Halogenated Hydrocarbons ◽

Male Rat ◽

Testosterone Metabolism ◽

Immature Male ◽

Aryl Hydrocarbons ◽

Tetrachlorodibenzo P Dioxin ◽

Linear Correlations

The effects of several toxic halogenated aryl hydrocarbons including 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, 2,3,4,7,8-pentachlorodibenzofuran, 3,3′,4,4′-tetrabromobiphenyl, 3,3′,4,4′5-pentachlorobiphenyl, and 3,3′,4,4′-tetrachloroazobenzene on hepatic microsomal testosterone hydroxylases were determined in the immature male rat. All of these compounds induced hepatic testosterone 7α-hydroxylase and inhibited testosterone 6β-, 16α-, 16β-, and 2α-hydroxylases and androstenedione formation. It was observed that there was a good correlation between the increase in testosterone 7α-hydroxylase by the halogenated hydrocarbons and their ability to cause body weight loss in the exposed rats. Comparable linear correlations were observed between toxicity and the decreased activities of other testosterone hydroxylases. The role of altered testosterone metabolism in the toxicity of halogenated aryl hydrocarbons is unknown.

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