Stored-Ion Spectroscopy

1983 ◽  
pp. 153-187 ◽  
Author(s):  
Hans Dehmelt
Keyword(s):  
2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Rianne E. van Outersterp ◽  
Sam J. Moons ◽  
Udo F. H. Engelke ◽  
Herman Bentlage ◽  
Tessa M. A. Peters ◽  
...  

AbstractThe identification of disease biomarkers plays a crucial role in developing diagnostic strategies for inborn errors of metabolism and understanding their pathophysiology. A primary metabolite that accumulates in the inborn error phenylketonuria is phenylalanine, however its levels do not always directly correlate with clinical outcomes. Here we combine infrared ion spectroscopy and NMR spectroscopy to identify the Phe-glucose Amadori rearrangement product as a biomarker for phenylketonuria. Additionally, we find analogous amino acid-glucose metabolites formed in the body fluids of patients accumulating methionine, lysine, proline and citrulline. Amadori rearrangement products are well-known intermediates in the formation of advanced glycation end-products and have been associated with the pathophysiology of diabetes mellitus and ageing, but are now shown to also form under conditions of aminoacidemia. They represent a general class of metabolites for inborn errors of amino acid metabolism that show potential as biomarkers and may provide further insight in disease pathophysiology.


2012 ◽  
Vol 76 (6) ◽  
pp. 683-686 ◽  
Author(s):  
N. V. Mamedov ◽  
V. A. Kurnaev ◽  
D. V. Ivanov ◽  
D. N. Sinel’nikov

2012 ◽  
Vol 23 (7) ◽  
pp. 1173-1181 ◽  
Author(s):  
Georgios Papadopoulos ◽  
Annette Svendsen ◽  
Oleg V. Boyarkin ◽  
Thomas R. Rizzo

2013 ◽  
Vol 60 (17) ◽  
pp. 1426-1438 ◽  
Author(s):  
Jochen Mikosch ◽  
Serguei Patchkovskii

Author(s):  
H. F. Beyer ◽  
R. Mann
Keyword(s):  

Author(s):  
Günther Werth
Keyword(s):  

1979 ◽  
pp. 999-1029 ◽  
Author(s):  
Hans A. Schuessler
Keyword(s):  

Radio Science ◽  
2016 ◽  
Vol 51 (8) ◽  
pp. 1385-1395 ◽  
Author(s):  
Yasutaka Imai ◽  
Tatsuya Nishi ◽  
Masatoshi Nishizaki ◽  
Sho Kawajiri ◽  
Yuto Muroki ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document