Role of Gabaergic and Glycinergic Transmissions in the Substantia Nigra in the Regulation of Dopamine Release in the Cat Caudate Nucleus

AbstractAppetitive locomotion is essential for animals to approach rewards, such as food and prey. The neuronal circuitry controlling appetitive locomotion is unclear. In a goal-directed behavior—predatory hunting, we show an excitatory brain circuit from the superior colliculus (SC) to the substantia nigra pars compacta (SNc) to enhance appetitive locomotion in mice. This tectonigral pathway transmits locomotion-speed signals to dopamine neurons and triggers dopamine release in the dorsal striatum. Synaptic inactivation of this pathway impairs appetitive locomotion but not defensive locomotion. Conversely, activation of this pathway increases the speed and frequency of approach during predatory hunting, an effect that depends on the activities of SNc dopamine neurons. Together, these data reveal that the SC regulates locomotion-speed signals to SNc dopamine neurons to enhance appetitive locomotion in mice.

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MUSCIMOL SUPPRESSES RCGU INCREASE IN THE SUBSTANTIA NIGRA AFTER DESTRUCTION OF THE CAUDATE NUCLEUS

Neuroreport ◽

10.1097/00001756-199205000-00016 ◽

1992 ◽

Vol 3 (5) ◽

pp. 441-444 ◽

Cited By ~ 2

Author(s):

Kimio Akagawa ◽

Makoto Saji ◽

Norihisa Aoki ◽

Tetsuo Kanno

Keyword(s):

Substantia Nigra ◽

Caudate Nucleus

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Further evidence for a role of δ-opiate receptors in the presynaptic regulation of newly synthesized dopamine release

European Journal of Pharmacology ◽

10.1016/0014-2999(86)90731-4 ◽

1986 ◽

Vol 126 (1-2) ◽

pp. 1-9 ◽

Cited By ~ 62

Author(s):

Francis Petit ◽

Michel Hamon ◽

Marie-Claude Fournie-Zaluski ◽

Bernard P. Roques ◽

Jacques Glowinski

Keyword(s):

Dopamine Release ◽

Opiate Receptors ◽

Presynaptic Regulation

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Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats

Experimental Brain Research ◽

10.1007/bf00230696 ◽

1989 ◽

Vol 78 (1) ◽

Cited By ~ 20

Author(s):

M.H. Millan ◽

B. Wardley-Smith ◽

M.J. Halsey ◽

B.S. Meldrum

Keyword(s):

High Pressure ◽

Nmda Receptor ◽

Substantia Nigra ◽

Substantia Nigra Pars Reticulata ◽

Entopeduncular Nucleus ◽

Neurological Syndrome

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Inhibition of dopamine release in the cat caudate nucleus by nigral application of glycine

European Journal of Pharmacology ◽

10.1016/0014-2999(78)90385-0 ◽

1978 ◽

Vol 47 (2) ◽

pp. 141-147 ◽

Cited By ~ 61

Author(s):

André Chéramy ◽

André Nieoullon ◽

Jacques Glowinski

Keyword(s):

Caudate Nucleus ◽

Dopamine Release

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Clinical and Neuropathological Findings of Acute Carbon Monoxide Toxicity in Chihuahuas Following Smoke Inhalation

Journal of the American Animal Hospital Association ◽

10.5326/0460259 ◽

2010 ◽

Vol 46 (4) ◽

pp. 259-264 ◽

Cited By ~ 18

Author(s):

Marc Kent ◽

Kate E. Creevy ◽

Alexander deLahunta

Keyword(s):

Carbon Monoxide ◽

Cerebral Cortex ◽

Case Report ◽

Substantia Nigra ◽

Supportive Care ◽

Caudate Nucleus ◽

Supplemental Oxygen ◽

Smoke Inhalation ◽

Dorsal Thalamus ◽

Initial Improvement

Three adult Chihuahuas were presented for evaluation after smoke inhalation during a house fire. All three dogs received supportive care and supplemental oxygen. After initial improvement, the dogs developed seizures. Despite anticonvulsant therapy and supportive care, the dogs died. The brains of two dogs were examined. Lesions were identified that were compatible with acute carbon monoxide (CO) toxicity. Lesions were confined to the caudate nucleus, the globus pallidus, and the substantia nigra bilaterally, as well as the cerebellum, cerebral cortex, and dorsal thalamus. This case report describes the clinicopathological sequelae in acute CO toxicity.

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