substantia nigra pars reticulata
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2022 ◽  
Vol 13 ◽  
Author(s):  
Meige Zheng ◽  
Yanchang Liu ◽  
Zhaoming Xiao ◽  
Luyan Jiao ◽  
Xian Lin

The loss of parvalbumin-positive (PV+) neurons in the substantia nigra pars reticulata (SNR) was observed in patients with end-stage Parkinson’s disease (PD) and our previously constructed old-aged Pitx3-A53Tα-Syn × Tau–/– triple transgenic mice model of PD. The aim of this study was to examine the progress of PV+ neurons loss. We demonstrated that, as compared with non-transgenic (nTg) mice, the accumulation of α-synuclein in the SNR of aged Pitx3-A53Tα-Syn × Tau–/– mice was increased obviously, which was accompanied by the considerable degeneration of PV+ neurons and the massive generation of apoptotic NeuN+TUNEL+ co-staining neurons. Interestingly, PV was not costained with TUNEL, a marker of apoptosis. PV+ neurons in the SNR may undergo a transitional stage from decreased expression of PV to increased expression of NeuN and then to TUNEL expression. In addition, the degeneration of PV+ neurons and the expression of NeuN were rarely observed in the SNR of nTg and the other triple transgenic mice. Hence, we propose that Tau knockout and α-syn A53T synergy modulate PV+ neurons degeneration staging in the SNR of aged PD-liked mice model, and NeuN may be suited for an indicator that suggests degeneration of SNR PV+ neurons. However, the molecular mechanism needs to be further investigated.


2021 ◽  
pp. 136278
Author(s):  
Marzieh Shahpari ◽  
Mohammad Reza Namavar ◽  
Leila Kamali Dolatabadi ◽  
Hadi Aligholi ◽  
Masoumeh Emamghoreishi

2021 ◽  
Vol 12 ◽  
Author(s):  
Libo Zhang ◽  
Shiqiu Meng ◽  
Wenjun Chen ◽  
Yun Chen ◽  
Enze Huang ◽  
...  

Persistent and stable drug memories lead to a high rate of relapse among addicts. A number of studies have found that intervention in addiction-related memories can effectively prevent relapse. Deep brain stimulation (DBS) exhibits distinct therapeutic effects and advantages in the treatment of neurological and psychiatric disorders. In addition, recent studies have also found that the substantia nigra pars reticulata (SNr) could serve as a promising target in the treatment of addiction. Therefore, the present study aimed to investigate the effect of DBS of the SNr on the reinstatement of drug-seeking behaviors. Electrodes were bilaterally implanted into the SNr of rats before training of methamphetamine-induced conditioned place preference (CPP). High-frequency (HF) or low-frequency (LF) DBS was then applied to the SNr during the drug-free extinction sessions. We found that HF DBS, during the extinction sessions, facilitated extinction of methamphetamine-induced CPP and prevented drug-primed reinstatement, while LF DBS impaired the extinction. Both HF and LF DBS did not affect locomotor activity or induce anxiety-like behaviors of rats. Finally, HF DBS had no effect on the formation of methamphetamine-induced CPP. In conclusion, our results suggest that HF DBS of the SNr could promote extinction and prevent reinstatement of methamphetamine-induced CPP, and the SNr may serve as a potential therapeutic target in the treatment of drug addiction.


2020 ◽  
pp. 112996
Author(s):  
Rafael Carvalho Almada ◽  
Tayllon dos Anjos-Garcia ◽  
Juliana Almeida da Silva ◽  
Glauce Regina Pigatto ◽  
Carsten T. Wotjak ◽  
...  

2020 ◽  
pp. 1-8
Author(s):  
Serap Sirvanci ◽  
Dilek Akakin ◽  
Medine Gulcebi İdrizoglu ◽  
Ozlem Tugce Kaya ◽  
Tugba Karamahmutoglu ◽  
...  

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