Lactosylceramide Synthase as a Therapeutic Target to Mitigate Multiple Human Diseases in Animal Models

2012 ◽  
pp. 153-169 ◽  
Author(s):  
Subroto Chatterjee ◽  
Nezar Alsaeedi
Keyword(s):  
Animal Models ◽  
Therapeutic Target ◽  
Human Diseases

scholarly journals Podocytes and the actin cytoskeleton as a feasible therapeutic target

2017 ◽  
Vol 118 (4) ◽  
Author(s):  
Sanja Sever ◽  
Changkyo Gu
Keyword(s):  
Animal Models ◽  
Actin Cytoskeleton ◽  
Therapeutic Target ◽  
Kidney Diseases ◽  
Glomerular Disease ◽  
Podocyte Injury ◽  
Chronic Kidney Diseases ◽  
Beneficial Effects ◽  
Actin Structure

Podocyte injury is a hallmark of the glomerular disease, which is a direct cause of chronic kidney diseases. Importantly, podocyte injury is a consequence of the dysregulation of the actin cytoskeleton. In diverse animal models of proteinuric glomerular disease, recovering the integrity of the actin structure in podocytes resulted in beneficial effects. In this review, we focus on the premise of targeting the actin cytoskeleton as a feasible therapeutics for treating chronic kidney diseases

scholarly journals New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models

2011 ◽  
Vol 10 (5) ◽  
pp. 258-265 ◽  
Author(s):  
P. N. Schofield ◽  
J. P. Sundberg ◽  
R. Hoehndorf ◽  
G. V. Gkoutos
Keyword(s):  
Animal Models ◽  
Human Diseases ◽  
New Approaches

Sensors for Proteolytic Activity Visualization and Their Application in Animal Models of Human Diseases

2019 ◽  
Vol 84 (S1) ◽  
pp. 1-18
Author(s):  
A. A. Bogdanov ◽  
I. D. Solovyev ◽  
A. P. Savitsky
Keyword(s):  
Animal Models ◽  
Proteolytic Activity ◽  
Human Diseases

Translational research of novel hormones: lessons from animal models and rare human diseases for common human diseases

2009 ◽  
Vol 87 (10) ◽  
pp. 1029-1039 ◽  
Author(s):  
Kazuwa Nakao ◽  
Akihiro Yasoda ◽  
Ken Ebihara ◽  
Kiminori Hosoda ◽  
Masashi Mukoyama
Keyword(s):  
Animal Models ◽  
Translational Research ◽  
Human Diseases
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