MSC Therapy in Animal Models and in Regenerative Medicine for Human Diseases

2009 ◽  
pp. 245-266
Author(s):  
Dov Zipori
Keyword(s):  
Animal Models ◽  
Regenerative Medicine ◽  
Human Diseases

scholarly journals New approaches to the representation and analysis of phenotype knowledge in human diseases and their animal models

2011 ◽  
Vol 10 (5) ◽  
pp. 258-265 ◽  
Author(s):  
P. N. Schofield ◽  
J. P. Sundberg ◽  
R. Hoehndorf ◽  
G. V. Gkoutos
Keyword(s):  
Animal Models ◽  
Human Diseases ◽  
New Approaches

Sensors for Proteolytic Activity Visualization and Their Application in Animal Models of Human Diseases

2019 ◽  
Vol 84 (S1) ◽  
pp. 1-18
Author(s):  
A. A. Bogdanov ◽  
I. D. Solovyev ◽  
A. P. Savitsky
Keyword(s):  
Animal Models ◽  
Proteolytic Activity ◽  
Human Diseases

Translational research of novel hormones: lessons from animal models and rare human diseases for common human diseases

2009 ◽  
Vol 87 (10) ◽  
pp. 1029-1039 ◽  
Author(s):  
Kazuwa Nakao ◽  
Akihiro Yasoda ◽  
Ken Ebihara ◽  
Kiminori Hosoda ◽  
Masashi Mukoyama
Keyword(s):  
Animal Models ◽  
Translational Research ◽  
Human Diseases

scholarly journals The Role of Animal Models in Evaluating Reasonable Safety and Efficacy for Human Trials of Cell-Based Interventions for Neurologic Conditions

2008 ◽  
Vol 29 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Alan Regenberg ◽  
Debra JH Mathews ◽  
David M Blass ◽  
Hilary Bok ◽  
Joseph T Coyle ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Animal Models ◽  
Regenerative Medicine ◽  
Therapeutic Agents ◽  
Preclinical Studies ◽  
Safety And Efficacy ◽  
Proper Role ◽  
New Treatments ◽  
Gathering Data

Progress in regenerative medicine seems likely to produce new treatments for neurologic conditions that use human cells as therapeutic agents; at least one trial for such an intervention is already under way. The development of cell-based interventions for neurologic conditions (CBI-NCs) will likely include preclinical studies using animals as models for humans with conditions of interest. This paper explores predictive validity challenges and the proper role for animal models in developing CBI-NCs. In spite of limitations, animal models are and will remain an essential tool for gathering data in advance of first-in-human clinical trials. The goal of this paper is to provide a realistic lens for viewing the role of animal models in the context of CBI-NCs and to provide recommendations for moving forward through this challenging terrain.

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