Resection of hepatic metastases from colorectal carcinoma

1994 ◽  
pp. 33-41 ◽  
Author(s):  
Horacio J. Asbun ◽  
Jane I. Tsao ◽  
Kevin S. Hughes
Keyword(s):  
Colorectal Carcinoma ◽  
Hepatic Metastases

A multifactorial analysis of prognostic factors in patients with liver metastases from colorectal carcinoma.

1983 ◽  
Vol 1 (11) ◽  
pp. 720-726 ◽  
Author(s):  
C J Lahr ◽  
S J Soong ◽  
G Cloud ◽  
J W Smith ◽  
M M Urist ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Colorectal Carcinoma ◽  
Survival Rates ◽  
Elevated Serum ◽  
Hepatic Metastases ◽  
Lactic Dehydrogenase ◽  
Serum Bilirubin Level ◽  
Elevated Alkaline Phosphatase ◽  
Multifactorial Analysis ◽  
Primary Colorectal Tumor

A multifactorial analysis was used to identify the dominant prognostic variables predicting survival rates of 175 patients with hepatic metastases from colorectal carcinoma. Seven of 22 parameters examined simultaneously were found to independently influence the median survival rate in these patients: (1) elevated alkaline phosphatase (p = 0.0004), (2) elevated serum bilirubin level (p = 0.0005), (3) location of hepatic metastases (unilateral or bilateral, p = 0.0022), (4) number of metastatic nodes involved (0, 1-5, greater than 5; p = 0.0148), (5) depressed serum albumin (p = 0.0217), (6) whether or not the primary colorectal tumor was resected (p = 0.0013), and (7) chemotherapy (given or withheld, p = 0.0439). The prothrombin time, serum lactic dehydrogenase, and the number of hepatic metastases also correlated with survival, but they did not independently predict survival rates after other more dominant factors were accounted for. A mathematical equation for predicting an individual patient's clinical course once they developed hepatic metastases was derived from this statistical analysis. In addition, a simple and clinically useful guide for predicting outcome was developed that integrated the two most important risk factors, alkaline phosphatase and bilirubin.

Hepatic metastases from colorectal carcinoma: Impact of surgical resection on the natural history

1990 ◽  
Vol 77 (11) ◽  
pp. 1241-1246 ◽  
Author(s):  
J. Scheele ◽  
R. Stangl ◽  
A. Altendorf-Hofmann
Keyword(s):  
Natural History ◽  
Colorectal Carcinoma ◽  
Surgical Resection ◽  
Hepatic Metastases

Prediction of the prognosis and surgical indications for pulmonary metastectomy from colorectal carcinoma in patients with combined hepatic metastases

Lung Cancer ◽  
2012 ◽  
Vol 75 (2) ◽  
pp. 209-212 ◽  
Author(s):  
Daigo Kawano ◽  
Sadanori Takeo ◽  
Shuichi Tsukamoto ◽  
Masakazu Katsura ◽  
Eri Masuyama ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Hepatic Metastases ◽  
Surgical Indications

A prospective evaluation of hepatic resection for colorectal carcinoma metastases to the liver: Gastrointestinal Tumor Study Group Protocol 6584.

1991 ◽  
Vol 9 (7) ◽  
pp. 1105-1112 ◽  
Author(s):  
G Steele ◽  
R Bleday ◽  
R J Mayer ◽  
A Lindblad ◽  
N Petrelli ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Median Survival ◽  
Curative Resection ◽  
Hepatic Metastases ◽  
Prospective Evaluation ◽  
Resection Group ◽  
Poor Predictor ◽  
Asymptomatic Patients ◽  
Noncurative Resection

We report here the results of the first multiinstitutional prospective evaluation of patients considered to have potentially resectable hepatic metastases from colorectal carcinoma. One hundred fifty-six patients were enrolled from 15 institutions. Six patients were subsequently excluded. One hundred fifty patients underwent surgery and are evaluable for analysis (median follow-up time, 3.1 years; range, 4 months to 5.1 years). Curative resection could be performed on 46% of patients (69 of 150), noncurative resection on 12% (18 of 150), while 42% were found to be unresectable (63 of 150). Thirty-day surgical mortality and morbidity rates in patients with attempted resection were 2.7% and 13%, respectively. The curative resection group was observed to have an improved median survival (37.1 months) compared with the noncurative resection group (21.2 months) and the unresectable group (16.5 months) (P less than .01). Computed tomographic (CT) scan was a poor predictor for resectability, and age was not a contraindication to curative resection. Preoperative carcinoembryonic antigen (CEA) values were also a poor predictor for resectability. However, the median CEA value 61 to 180 days postsurgery was significantly higher in unresectable patients compared with median CEA levels in noncuratively and curatively resected groups (P less than .01). Our results imply that curative resection leads to an increase in median survival. Noncurative resection provides no benefit to asymptomatic patients, since unresectable and noncurative resection groups have similar life expectancies. Longer follow-up will be needed to demonstrate the ultimate impact of curative resection on survival.

Occult hepatic metastases in colorectal carcinoma

1986 ◽  
Vol 73 (12) ◽  
pp. 1046-1046 ◽  
Author(s):  
I. S. Benjamin ◽  
L. H. Blumgart ◽  
I. G. Finlay ◽  
C. S. McArdle
Keyword(s):  
Colorectal Carcinoma ◽  
Hepatic Metastases

Outcomes of hepatic artery infusion therapy for hepatic metastases from colorectal carcinoma after radiological placement of infusion catheters

2007 ◽  
Vol 33 (6) ◽  
pp. 741-745 ◽  
Author(s):  
S. Sameshima ◽  
H. Horikoshi ◽  
K. Motegi ◽  
S. Tomozawa ◽  
I. Hirayama ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Hepatic Artery ◽  
Hepatic Metastases ◽  
Infusion Therapy ◽  
Hepatic Artery Infusion

The Clinical Relevance of Tumor Marker Cea, Ca 19-9 in Regional Chemotherapy of Hepatic Metastases of Colorectal Carcinoma

1988 ◽  
Vol 3 (2) ◽  
pp. 101-106 ◽  
Author(s):  
F. Safi ◽  
R. Roscher ◽  
R. Bittner ◽  
H.G. Beger
Keyword(s):  
Complete Remission ◽  
Colorectal Carcinoma ◽  
Liver Metastases ◽  
Clinical Relevance ◽  
Hepatic Metastases ◽  
Tumor Stage ◽  
Regional Chemotherapy ◽  
Danger Signal ◽  
Tumor Spread ◽  
Angio Ct

Up to December 1986, 50 patients with documented hepatic metastases from colorectal carcinoma were treated with 5-fluoro-2-deoxyuridine (FUDR) using Infusaid pumps. The response of liver metastases to regional chemotherapy was studied by computerized tomography (CT) and carcino-embryonal antigen (CEA), and/or CA 19-9 antigen serum assays. Preoperative CEA values were pathological in 94% of the patients but only 48% had a pathological concentration of the antigen CA 19-9 of over 37 U/ml. The course of CEA and CA 19-9 in combination with the arterial angio-CT reflected the response of liver metastases to regional chemotherapy. A decrease or normalisation of CEA and CA 19-9 after the beginning of therapy is an indication of partial or complete remission of metastases (68% of the patients showed lowered CEA serum values). If the marker continues to rise in serum this is a danger signal of progression of liver metastases or of extrahepatic tumor spread if the tumor stage in the liver remains unchanged.

Intrahepatic Artery 5-Fluorouracil and Mitomycin-C in Previously Untreated Patients with Hepatic Metastases from Colorectal Carcinoma

1982 ◽  
Vol 147 (3) ◽  
pp. 220-223 ◽  
Author(s):  
John D. Cowan ◽  
James Easterbrook ◽  
Glenn M. Mills ◽  
Joseph D. McCracken
Keyword(s):  
Colorectal Carcinoma ◽  
Mitomycin C ◽  
Hepatic Metastases

Continuous intrahepatic infusion of floxuridine and leucovorin through an implantable pump for the treatment of hepatic metastases from colorectal carcinoma

Cancer ◽  
1990 ◽  
Vol 65 (11) ◽  
pp. 2446-2450 ◽  
Author(s):  
Nancy Kemeny ◽  
Alfred Cohen ◽  
Joseph R. Bertino ◽  
Elin R. Sigurdson ◽  
Jose Botet ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Hepatic Metastases ◽  
Implantable Pump
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