Biological Dosimetry for Gadolinium Neutron Capture Reaction

1993 ◽  
pp. 245-248 ◽  
Author(s):  
Koichi Tokuuye ◽  
Nobuhiko Tokita ◽  
Yasuyuki Akine ◽  
Tooru Kobayashi ◽  
Keiji Kanda
Keyword(s):  
Neutron Capture ◽  
Neutron Capture Reaction ◽  
Capture Reaction ◽  
Biological Dosimetry

scholarly journals Detailed low-spin spectroscopy of Ni65 via neutron capture reaction

2020 ◽  
Vol 102 (6) ◽  
Author(s):  
C. Porzio ◽  
C. Michelagnoli ◽  
N. Cieplicka-Oryńczak ◽  
M. Sferrazza ◽  
S. Leoni ◽  
...  
Keyword(s):  
Neutron Capture ◽  
Neutron Capture Reaction ◽  
Capture Reaction

Levels of 188Re nucleus populated in thermal neutron capture reaction

2016 ◽  
Vol 947 ◽  
pp. 76-126 ◽  
Author(s):  
J. Bērziņš ◽  
T. Krasta ◽  
L. Simonova ◽  
M. Balodis ◽  
V. Bondarenko ◽  
...  
Keyword(s):  
Thermal Neutron ◽  
Neutron Capture ◽  
Thermal Neutron Capture ◽  
Neutron Capture Reaction ◽  
Capture Reaction

scholarly journals Translational Evaluation of a Dodecaborated Albumin Conjugate With Maleimide as a Boron Delivery System for a Neutron Capture Reaction to an F98 Rat Glioma Model

2021 ◽  
Author(s):  
Hideki Kashiwagi ◽  
Shinji Kawabata ◽  
Kohei Yoshimura ◽  
Yusuke Fukuo ◽  
Takuya Kanemitsu ◽  
...  
Keyword(s):  
Delivery System ◽  
Neutron Irradiation ◽  
Neutron Capture ◽  
Control Group ◽  
Clinical Settings ◽  
Neutron Capture Reaction ◽  
Capture Reaction ◽  
Rat Glioma ◽  
F98 Rat Glioma ◽  
Boron Neutron Capture

Abstract Boron neutron capture therapy (BNCT) is a biologically targeted, cell-selective particle irradiation therapy that utilizes the nuclear capture reaction of boron and neutron. Recently, accelerator neutron generators have been used in clinical settings, and expectations for developing new boron compounds are growing. In this study, we focused on serum albumin, a well-known drug delivery system, and developed maleimide-functionalized closo-dodecaborate albumin conjugate (MID-AC) as a boron carrying system for BNCT. Our biodistribution experiment involved F98 glioma-bearing rat brain tumor models systemically administered with MID-AC and demonstrated accumulation and long retention of boron. Our BNCT study with MID-AC observed statistically significant prolongation of the survival rate compared to the control groups, with results comparable to BNCT study with boronophenylalanine (BPA) which is the standard use of in clinical settings. Each median survival time was as follows: untreated control group; 24.5 days, neutron-irradiated control group; 24.5 days, neutron irradiation following 2.5 hours after termination of intravenous administration (i.v.) of BPA; 31.5 days, and neutron irradiation following 2.5 or 24 hours after termination of i.v. of MID-AC; 33.5 or 33.0 days, respectively. The biological effectiveness factor of MID-AC for F98 rat glioma was estimated based on these survival times and found to be higher to 12. This tendency was confirmed in BNCT 24 hours after MID-AC administration. MID-AC induces an efficient boron neutron capture reaction because the albumin contained in MID-AC is retained in the tumor and has a considerable potential to become an effective delivery system for BNCT in treating high-grade gliomas.

Investigation of radioactive samples for neutron capture reaction measurements using energy-resolved neutron imaging

2021 ◽  
pp. 108828
Author(s):  
Mariko Segawa ◽  
Yosuke Toh ◽  
Tetsuya Kai ◽  
Atsushi Kimura ◽  
Shoji Nakamura
Keyword(s):  
Neutron Capture ◽  
Neutron Imaging ◽  
Neutron Capture Reaction ◽  
Capture Reaction

Prompt Gamma Rays Emitted from the Neutron Capture Reaction of 74Ge

2011 ◽  
Vol 59 (2(3)) ◽  
pp. 1832-1835 ◽  
Author(s):  
K. Y. Hara ◽  
T. Kin ◽  
M. Oshima ◽  
S. Nakamura ◽  
A. Kimura ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Neutron Capture ◽  
Prompt Gamma ◽  
Neutron Capture Reaction ◽  
Capture Reaction

Killing Effects of Gadolinium Neutron Capture Reaction on Brain Tumors

1992 ◽  
pp. 407-410 ◽  
Author(s):  
M. Takagaki ◽  
Y. Oda ◽  
S. Miyatake ◽  
H. Kikuchi ◽  
T. Kobayashi ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Neutron Capture ◽  
Neutron Capture Reaction ◽  
Capture Reaction

The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer

2020 ◽  
Vol 165 ◽  
pp. 109271
Author(s):  
Shou Wang ◽  
Kazuyo Igawa ◽  
Ryo Ogawara ◽  
Mitsuru Suda ◽  
Tsuyoshi Hamano ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Neutron Capture ◽  
Evaluation System ◽  
Neutron Capture Reaction ◽  
Capture Reaction ◽  
Boron Neutron Capture

Spectroscopic Study of63Ni via Cold Neutron Capture Reaction: I. Nuclear Structure of63Ni

2012 ◽  
Vol 81 (8) ◽  
pp. 084201
Author(s):  
Masumi Oshima ◽  
Tadahiro Kin ◽  
Shoji Nakamura ◽  
Michio Honma ◽  
Futoshi Minato ◽  
...  
Keyword(s):  
Spectroscopic Study ◽  
Nuclear Structure ◽  
Neutron Capture ◽  
Cold Neutron ◽  
Neutron Capture Reaction ◽  
Capture Reaction
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