Neuroendocrine Changes during the Course of Neuroleptic Treatment of Schizophrenic Patients

AbstractLevels of immunoglobulins were measured in 32 schizophrenic patients with tardive dyskinesia and 34 schizophrenic patients without tardive dyskinesia. The duration of neuroleptic treatment in years was similar in the two groups. The serum immunoglobulin concentrations (mg%) were found to be significantly different in the two groups; IGA and IGM levels were higher in patients with tardive dyskinesia. The present results may be explained on the basis of dysfunction of the immunological system in tardive dyskinesia.

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Relevance of the dopamine D2 receptor blockade in clinical response to neuroleptic treatment in schizophrenic patients

Schizophrenia Research ◽

10.1016/0920-9964(89)90243-0 ◽

1989 ◽

Vol 2 (1-2) ◽

pp. 207

Author(s):

Ana Hitri ◽

Parvathi Mohan ◽

Dharmber Sinha ◽

James Harrold ◽

BruceI. Diamond ◽

...

Keyword(s):

Clinical Response ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Receptor Blockade ◽

Neuroleptic Treatment ◽

Dopamine D2 ◽

Schizophrenic Patients

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Neuroleptic Treatment of Schizophrenic Patients: How Do Haloperidol and Clozapine Normalize Brain Blood Flow Patterns Associated with a Difficult Tone Recognition Task?

Search for the Causes of Schizophrenia ◽

10.1007/978-3-642-47076-9_26 ◽

1999 ◽

pp. 355-365 ◽

Cited By ~ 2

Author(s):

H. H. Holcomb ◽

A. C. Lahti ◽

M. Weiler ◽

D. R. Medoff ◽

C. A. Tamminga

Keyword(s):

Blood Flow ◽

Recognition Task ◽

Flow Patterns ◽

Brain Blood Flow ◽

Neuroleptic Treatment ◽

Schizophrenic Patients ◽

Tone Recognition ◽

Blood Flow Patterns

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Adherence to neuroleptic treatment in psychiatric practices: A retrospective study of 55 practices with more than 5000 bipolar and schizophrenic patients in Germany

Psychiatry Research ◽

10.1016/j.psychres.2020.112758 ◽

2020 ◽

Vol 284 ◽

pp. 112758

Author(s):

Jens Bohlken ◽

Marcel Konrad ◽

Karel Kostev

Keyword(s):

Retrospective Study ◽

Neuroleptic Treatment ◽

Schizophrenic Patients

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Low CSF Concentrations of Cyclic GMP in Schizophrenia

The British Journal of Psychiatry ◽

10.1192/bjp.142.3.288 ◽

1983 ◽

Vol 142 (3) ◽

pp. 288-291 ◽

Cited By ~ 26

Author(s):

W. F. Gattaz ◽

H. Cramer ◽

H. Beckmann

Keyword(s):

Cerebrospinal Fluid ◽

Cyclic Gmp ◽

Homovanillic Acid ◽

Healthy Controls ◽

Neuroleptic Treatment ◽

Cholinergic Activity ◽

Schizophrenic Patients ◽

Csf Levels

SummaryIncreasing evidence suggests that the concentrations of cyclic guanosine 3′5′-monophosphate (cGMP) in the cerebrospinal fluid (CSF) may reflect central cholinergic activity. When the concentrations of this nucleotide in the CSF from 28 schizophrenic patients (13 without and 15 with neuroleptic treatment) and 16 psychiatrically healthy controls was determined the schizophrenics showed significantly lower CSF levels of cGMP as compared to controls.As dopamine and homovanillic acid concentrations were not altered in these CSF samples, this finding of reduced cGMP suggests a cholinergic-dopaminergic imbalance in schizophrenia, with a reduction of the former and consequently a relative dominance of the latter.

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