Relevance of the dopamine D2 receptor blockade in clinical response to neuroleptic treatment in schizophrenic patients

1989 ◽  
Vol 2 (1-2) ◽  
pp. 207
Author(s):  
Ana Hitri ◽  
Parvathi Mohan ◽  
Dharmber Sinha ◽  
James Harrold ◽  
BruceI. Diamond ◽  
...  
Keyword(s):  
Clinical Response ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Blockade ◽  
Neuroleptic Treatment ◽  
Dopamine D2 ◽  
Schizophrenic Patients

Relationships between dopamine-D2 receptor blockade and dopamine synthesis during neuroleptic treatment

1997 ◽  
Vol 42 (1) ◽  
pp. 230S
Author(s):  
G. Trolin ◽  
M. Bela ◽  
O. Gefvert ◽  
B. Lángström ◽  
S. Valind ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine Synthesis ◽  
Receptor Blockade ◽  
Neuroleptic Treatment ◽  
Dopamine D2

Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole

2008 ◽  
Vol 18 (12) ◽  
pp. 897-907 ◽  
Author(s):  
Jun Soo Kwon ◽  
Euitae Kim ◽  
Do-Hyung Kang ◽  
Jung Seok Choi ◽  
Kyung-Sang Yu ◽  
...  
Keyword(s):  
Clinical Response ◽  
Dopamine D2 Receptor ◽  
Receptor Gene ◽  
D2 Receptor ◽  
Dopamine D2

Dopamine D2 Receptor Blockade and Antimigraine Action of Flunarizine

Cephalalgia ◽  
1994 ◽  
Vol 14 (3) ◽  
pp. 235-240 ◽  
Author(s):  
C Wöber ◽  
T Brücke ◽  
C Wöber-Bingöl ◽  
S Asenbaum ◽  
P Wessely ◽  
...  
Keyword(s):  
Single Photon ◽  
Dopamine D2 Receptor ◽  
Photon Emission ◽  
D2 Receptor ◽  
High Specificity ◽  
D2 Receptors ◽  
Binding Potential ◽  
Receptor Blockade ◽  
Dopamine D2

We studied in vivo the influence of flunarizine on dopamine D2 receptors and investigated whether dopamine D2 receptor blockade is involved in its antimigraine action. Eleven migraine patients, treated with flunarizine, 10 mg per day, underwent single photon emission computer tomography (SPECT) using [123I] labeled iodobenzamide, a ligand with high affinity and high specificity for D2 receptors. There was a reduction of the dopamine D2 receptor binding potential in all patients compared to age-matched controls. The efficacy of flunarizine in migraine prophylaxis failed to correlate with the degree of the dopamine D2 receptor blockade. The antimigraine action of flunarizine may not involve antidopaminergic mechanisms.

Dopamine D2 receptor gene −141C Insertion/Deletion polymorphism in Turkish schizophrenic patients

2010 ◽  
Vol 38 (2) ◽  
pp. 1407-1411 ◽  
Author(s):  
Hulyam Kurt ◽  
Miris Dikmen ◽  
Ayşe Basaran ◽  
Cinar Yenilmez ◽  
Figen Ozdemir ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
Receptor Gene ◽  
D2 Receptor ◽  
Deletion Polymorphism ◽  
Dopamine D2 ◽  
Schizophrenic Patients
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