Assessing Selected Aspects of Adequacy of the Growth Hormone-Somatomedin Axis in Short Children with Quantitatively Normal Growth Hormone Secretion

1988 ◽  
pp. 263-270
Author(s):  
D. P. Dempsher ◽  
S. E. Tollefsen ◽  
E. Heath-Monnig ◽  
B. Trivedi ◽  
J. R. Gavin ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Growth ◽  
Short Children

scholarly journals Does priming with sex steroids improve the diagnosis of normal growth hormone secretion in short children?

2014 ◽  
Vol 18 (7) ◽  
pp. 80 ◽  
Author(s):  
Ashraf Soliman ◽  
Ashraf Adel ◽  
Aml Sabt ◽  
Elkhansa Elbukhari ◽  
Hannah Ahmed ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Sex Steroids ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Growth ◽  
Short Children

Specific abnormalities in a visual motor psychological test in short children with abnormal growth hormone secretion

1997 ◽  
Vol 86 (2) ◽  
pp. 154-159 ◽  
Author(s):  
A Andronikof-Sanglade ◽  
A Fjellestad-Paulsen ◽  
S Ricard-Malivoir ◽  
D Evain-Brion
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Psychological Test ◽  
Abnormal Growth ◽  
Short Children ◽  
Visual Motor

Normal growth hormone secretion in overweight young adults with Down syndrome

2010 ◽  
Vol 20 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Å. Myrelid ◽  
P. Frisk ◽  
M. Stridsberg ◽  
G. Annerén ◽  
J. Gustafsson
Keyword(s):  
Growth Hormone ◽  
Young Adults ◽  
Down Syndrome ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Growth

scholarly journals A Boy with "transient" Growth Hormone Deficiency in Prepubertal Stage Despite Normal Growth Hormone Secretion in Childhood and after Puberty

2007 ◽  
Vol 54 (6) ◽  
pp. 1015-1019
Author(s):  
Ken-ichi KASHIMADA ◽  
Toshikazu ONISHI ◽  
Makoto ONO ◽  
Kentaro MIYAI ◽  
Masayasu OHTA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Normal Growth ◽  
Hormone Deficiency ◽  
Transient Growth

Plasma IGFBP-3 and its relationship with quantitative growth hormone secretion in short children

1993 ◽  
Vol 39 (4) ◽  
pp. 427-432 ◽  
Author(s):  
Moshe Phillip ◽  
Stuart A. Chalew ◽  
A. Avinoam Kowarski ◽  
Mark A. Stene
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Short Children ◽  
Igfbp 3

Desensitization from long-term intranasal treatment with hexarelin does not interfere with the biological effects of this growth hormone-releasing peptide in short children

1996 ◽  
Vol 134 (6) ◽  
pp. 716-719 ◽  
Author(s):  
Beatrice Klinger ◽  
Aviva Silbergeld ◽  
Romano Deghenghi ◽  
Jenny Frenkel ◽  
Zvi Laron
Keyword(s):  
Growth Hormone ◽  
Growth Velocity ◽  
Biological Effects ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Human Growth ◽  
Pediatric Endocrinology ◽  
Short Children ◽  
The Mean

Klinger B, Silbergeld A, Deghenghi R, Frenkel J, Laron Z. Desensitization from long-term intranasal treatment with hexarelin does not interfere with the biological effects of this growth hormonereleasing peptide in short children. Eur J Endocrinol 1996;134:716–9. ISSN 0804–4643 A clinical, prospective experiment was carried out to determine whether long-term intranasal administration of the growth hormone-releasing peptide hexarelin (His-d-2-methyl-Trp-Ala-Trp-d-Phe-Lys-NH2) affects pituitary growth hormone secretion. Hexarelin (60 μg/kg t.i.d.) was administered to seven prepubertal constitutionally short children (mean age ±sd = 7.6 ± 2.4 years). Serum human growth hormone (hGH) response to an intranasal (20 μg/kg) and intravenous (1 μg/kg) bolus of hexarelin before, during and after 6–10 months of treatment was measured. The mean (±sd) peak rise of hGH to the intranasal bolus before treatment was 70.6 ± mU/I. After 7 days of hexarelin treatment, mean peak values dropped to 34.1 ±15.7 mU/l (p < 0.002) and thereafter remained constant for 6 months of treatment at 37.5 10.3 ±mU/l (p < 0.03). The pretreatment peak to the iv hexarelin bolus was 84.8 52.5 ±mU/l, and at the end of the treatment period it was 19.8 10.9 ±mU/l (p < 0.05). Three months after stopping treatment the mean (±sd) hGH response rose to 42.1 ±4.7 mU/l (p < 0.005). Growth velocity increased from 5.3±0.9 cm/year (before treatment) to 7.4 1.6 cm/year at ±6–10 months of treatment (p < 0.005). In conclusion, the partial suppression of pituitary hGH responsiveness to long-term intranasal hexarelin treatment, probably due to desensitization, does not affect the observed increase in growth velocity. Z Laron, Pediatric Endocrinology, 11 El Al Street, Ramat Efal, 52960, Israel

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