Altered Phospholipase Activities Related to α1-Adrenergic Receptor Supersensitivity of Aortas from Aldosterone-Salt Hypertensive Rats

1991 ◽  
pp. 55-69 ◽  
Author(s):  
Allan W. Jones ◽  
Shivendra D. Shukla ◽  
Brinda B. Geisbuhler ◽  
Susan B. Jones ◽  
Jacquelyn M. Smith
Keyword(s):  
Adrenergic Receptor ◽  
Hypertensive Rats ◽  
Receptor Supersensitivity

Gene regulation of beta-1-adrenergic receptor in genetically hypertensive rats

1993 ◽  
Vol 11 (5) ◽  
pp. S64???S65 ◽  
Author(s):  
Maurizio Castellano ◽  
Martin Paul ◽  
Marina Beschi ◽  
Jurgen Bachmann ◽  
Damiano Rizzoni ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Adrenergic Receptor ◽  
Hypertensive Rats ◽  
Genetically Hypertensive Rats ◽  
Genetically Hypertensive

Lithium effects on adrenergic receptor supersensitivity in rat brain

1979 ◽  
Vol 58 (1) ◽  
pp. 85-86 ◽  
Author(s):  
Susan Treiser ◽  
Kenneth J. Kellar
Keyword(s):  
Rat Brain ◽  
Adrenergic Receptor ◽  
Receptor Supersensitivity

scholarly journals Vaccine Targeted Alpha 1D-Adrenergic Receptor for Hypertension

Hypertension ◽  
2019 ◽  
Vol 74 (6) ◽  
pp. 1551-1562 ◽  
Author(s):  
Chang Li ◽  
Xiaole Yan ◽  
Danyu Wu ◽  
Kai Zhang ◽  
Xin Liang ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Short Term ◽  
Term Study ◽  
Spontaneously Hypertensive ◽  
Short Term Study ◽  
Immune Mediated ◽  
Long Term Observation

The α1-AR (α1 adrenergic receptor) blockers currently on the market cannot meet clinical needs because of low-selectivity for subtypes of α1-ARs, short half-life, and uncertain role in cardiovascular end point events. The study sought to find a vaccine specifically against α1D-AR (α1D-adrenergic receptor) for treating hypertension. A short peptide ADR-004 (cgiteeagy) belonging to α1D-AR was screened, and the ADRQβ-004 vaccine was produced and injected into spontaneously hypertensive rats model (including a short-term study, 10 weeks, and a long-term observation study, 39 weeks) and NG-nitro- l -arginine methyl ester + spontaneously hypertensive rats model (15 weeks). The antihypertensive effect and target organ protection of the ADRQβ-004 vaccine were carefully evaluated. The possible immune-mediated damage was detected in normal vaccinated Sprague Dawley rats. The ADR-004 peptide has perfect immunogenicity, and the ADRQβ-004 vaccine could induce strong antibody production. In the short-term study, the ADRQβ-004 vaccine averagely decreased the systolic blood pressure of spontaneously hypertensive rats up to 15 mm Hg and that of NG-nitro- l -arginine methyl ester+spontaneously hypertensive rats up to 29 mm Hg. In the long-term observation model, the antihypertensive effect of the ADRQβ-004 vaccine was quite stable, and the average decline of systolic blood pressure was 22 mm Hg. The ADRQβ-004 vaccine effectively prevented vascular structural remodeling, cardiac hypertrophy and fibrosis, and renal injury of hypertensive animals, superior to prazosin at renal level. Moreover, the ADRQβ-004 vaccine obviously downregulated the expression of α1D-AR, but not α1A-AR. Additionally, no significant immune-mediated damage was detected in immunized animals. The present results demonstrate that the ADRQβ-004 vaccine may provide a novel and promising method for the treatment of hypertension.

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