Isolated Preparations: Dose—Response Data

1979 ◽  
pp. 137-170 ◽  
Author(s):  
Ronald J. Tallarida ◽  
Leonard S. Jacob
Keyword(s):  
Dose Response ◽  
Response Data

scholarly journals Weighted mixed-effects dose–response models for tables of correlated contrasts

2021 ◽  
Vol 21 (2) ◽  
pp. 320-347
Author(s):  
Nicola Orsini
Keyword(s):  
Dose Response ◽  
Response Pattern ◽  
Mixed Effects ◽  
Data Generation ◽  
Measures Of Association ◽  
Response Models ◽  
Response Data ◽  
Hazard Ratios ◽  
Health Related ◽  
Generation Mechanisms

Recognizing a dose–response pattern based on heterogeneous tables of contrasts is hard. Specification of a statistical model that can consider the possible dose–response data-generating mechanism, including its variation across studies, is crucial for statistical inference. The aim of this article is to increase the understanding of mixed-effects dose–response models suitable for tables of correlated estimates. One can use the command drmeta with additive (mean difference) and multiplicative (odds ratios, hazard ratios) measures of association. The postestimation command drmeta_graph greatly facilitates the visualization of predicted average and study-specific dose–response relationships. I illustrate applications of the drmeta command with regression splines in experimental and observational data based on nonlinear and random-effects data-generation mechanisms that can be encountered in health-related sciences.

Archiving of Food Samples from Restaurants and Caterers—Quantitative Profiling of Outbreaks of Foodborne Salmonellosis in Japan

2004 ◽  
Vol 67 (9) ◽  
pp. 2024-2032 ◽  
Author(s):  
FUMIKO KASUGA ◽  
MASAMITSU HIROTA ◽  
MASAMICHI WADA ◽  
TOSHIHIKO YUNOKAWA ◽  
HAJIME TOYOFUKU ◽  
...  
Keyword(s):  
Dose Response ◽  
Storage System ◽  
Epidemiological Data ◽  
Food Samples ◽  
Food Storage ◽  
Disease Rate ◽  
Data Sets ◽  
Response Data ◽  
Quantitative Profiling

The Ministry of Health, Labor and Welfare (former MHW) of Japan issued a Directive in 1997 advising restaurants and caterers to freeze portions of both raw food and cooked dishes for at least 2 weeks. This system has been useful for determining vehicle foods at outbreaks. Enumeration of bacteria in samples of stored food provide data about pathogen concentrations in the implicated food. Data on Salmonella concentrations in vehicle foods associated with salmonellosis outbreaks were collected in Japan between 1989 and 1998. The 39 outbreaks that occurred during this period were categorized by the settings where the outbreaks took place, and epidemiological data from each outbreak were summarized. Characteristics of outbreak groups were analyzed and compared. The effect of new food-storage system on determination of bacterial concentration was evaluated. Freezing and nonfreezing conditions prior to microbial examination were compared in the dose-response relationship. Data from outbreaks in which implicated foods had been kept frozen suggested apparent correlation between the Salmonella dose ingested and the disease rate. Combined with results of epidemiological investigation, quantitative data from the ingested pathogen could provide complete dose-response data sets.

A systematic review of experimental animal studies on microbial bioaerosols: Dose-response data for the derivation of exposure limits

2019 ◽  
Vol 222 (2) ◽  
pp. 249-259 ◽  
Author(s):  
Mihai Zamfir ◽  
Doris G. Gerstner ◽  
Sandra M. Walser ◽  
Jürgen Bünger ◽  
Thomas Eikmann ◽  
...  
Keyword(s):  
Systematic Review ◽  
Experimental Animal ◽  
Dose Response ◽  
Animal Studies ◽  
Exposure Limits ◽  
Response Data

Multinomial dose-response data

2019 ◽  
pp. 85-93
Author(s):  
Christian Ritz ◽  
Signe Marie Jensen ◽  
Daniel Gerhard ◽  
Jens Carl Streibig
Keyword(s):  
Dose Response ◽  
Response Data

The pharmacology of an insect ganglion: actions of carbamylcholine and acetylcholine

1976 ◽  
Vol 64 (1) ◽  
pp. 13-23
Author(s):  
D. B. Sattelle ◽  
A. S. McClay ◽  
R. J. Dowson ◽  
J. J. Callec
Keyword(s):  
Synaptic Transmission ◽  
Dose Response ◽  
Response Curve ◽  
Periplaneta Americana ◽  
Electrophysiological Recording ◽  
Cholinergic Agonists ◽  
Giant Fibre ◽  
Response Data ◽  
Gap Technique ◽  
Monosynaptic Epsp

1. Methods for presenting dose-response data for the ganglionic actions of cholinergic agonists (e.g. carbamylcholine) are compared, using the mannitol-gap technique for electrophysiological recording of synaptic events at the cercal nerve, giant fibre synapse of the sixth abdominal ganglion of the cockroach Periplaneta americana. 2. At concentrations around 10(−5)M, carbamylcholine has no effect on ganglionic polarization but potentiates the monosynaptic EPSP. At 10(−4)M and higher concentrations, ganglionic depolarization is accompanied by a reduction of EPSP. 3. Pretreatment with eserine (10(−6) M) considerably shifts the dose-response curve for acetylcholine so that synaptic transmission is consistently sensitive to 10(−6) M acetylcholine.

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