experimental animal
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2022 ◽  
Vol Volume 15 ◽  
pp. 205-215
Author(s):  
Jin-Li Guo ◽  
Xian-Yan Yan ◽  
Qing-Li Zhao ◽  
Chao-Na Gao ◽  
Chen-Hui Wei ◽  
...  

2021 ◽  
Vol 148 (12) ◽  
pp. 24-31
Author(s):  
Le Thanh Xuan ◽  
Le Thi Nhat Ngoc ◽  
Tran Quang Minh ◽  
Vu Viet Hang ◽  
Pham Thi Van Anh ◽  
...  

The present study aimed to investigate the sub-chronic toxicity of “Phong thap dan” (PTD) tablets through oral administration in experimental animal. The sub-chronic toxicity was evaluated by the WHO recommendation in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose). In the sub-chronic experimental group, the PTD was administered orally daily for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were no behavioral and physiological change or sign of toxicity. The result of the hematological and biological parameters after administration of PTD tablets showed no change. The histopathology analysis of livers and kidneys indicated that no significant difference was observed between the exposed and unexposed rat groups. In conclusion, “Phong thap dan” tablets did not produce sub-chronic toxicity in Wistar rats.


2021 ◽  
pp. 190-198
Author(s):  
Italo Soares Eneias ◽  
Ana Rita Pinheiro Barcessat ◽  
Alana Patrícia Lima Ferreira ◽  
Ana Vitoria Gonçalves de Oliveira Cruz ◽  
Carla Emanuela Xavier Silva ◽  
...  
Keyword(s):  

2021 ◽  
pp. 1-5
Author(s):  
Sergey Anatol'evich Karpishchenko ◽  
Mikhail Ur’evich Ulupov ◽  
Maria Ur’evna Boboshko ◽  
Olga Nikolaevna Sopko ◽  
Anna Nikolaevna Bervinova

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1609
Author(s):  
Mari Carmen Gómez-de Frutos ◽  
Fernando Laso-García ◽  
Iván García-Suárez ◽  
Luke Diekhorst ◽  
Laura Otero-Ortega ◽  
...  

Ultrasound is a noninvasive technique that provides real-time imaging with excellent resolution, and several studies demonstrated the potential of ultrasound in acute ischemic stroke monitoring. However, only a few studies were performed using animal models, of which many showed ultrasound to be a safe and effective tool also in therapeutic applications. The full potential of ultrasound application in experimental stroke is yet to be explored to further determine the limitations of this technique and to ensure the accuracy of translational research. This review covers the current status of ultrasound applied to monitoring and treatment in experimental animal models of stroke and examines the safety, limitations, and future perspectives.


2021 ◽  
Vol 108 (Supplement_8) ◽  
Author(s):  
Gillian Manchip ◽  
Alex Shaw ◽  
Sarah Herrick

Abstract Aim Adhesions are fibrous bands of scar tissue that form following peritoneal injury, commonly intra-abdominal surgery, and are associated with serious morbidity such as small bowel obstruction and pain. Surgical meshes used for incisional hernia repair are associated with increased incidence and severity of adhesions. There is limited consensus on which mesh may induce the least adhesions following incisional hernia repair, and most previous data has come from experimental animal models. We aimed to evaluate existing primary research to investigate whether biological mesh limits adhesion formation compared to synthetic or biosynthetic mesh when used in patients for incisional hernia repair and also to assess whether there is correlation with existing animal model data. Material and Methods A systematic search was conducted on PubMed and EMBASE. The number of mesh-related adhesions, character of adhesions and adhesion-related complications were documented. Results were compared to previously published results from animal models. Results Thirty-two studies were included, 11 of which did not document whether the adhesions were mesh related. A total of 14,161 participants underwent incisional hernia repair, 8,526 of whom were included in follow-up analysis. Overall, 9.7% developed adhesions. Biological mesh induced a high rate of dense adhesions, whereas biosynthetic mesh induced loose, filmy adhesions suggested to cause fewer complications. These findings were similar to findings from experimental animal models. Conclusions Bio-synthetic mesh was superior in causing fewer and less dense adhesions. Further analysis of mesh-induced adhesion formation on a larger scale is required to fully understand the consequences of different mesh types.


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