Evidence for Free Radical Generation in Vivo during Cardiac Ischemia and Reperfusion

1990 ◽  
pp. 89-97
Author(s):  
Roberto Bolli ◽  
Bharat S. Patel ◽  
Mohamed O. Jeroudi ◽  
Edward K. Lai ◽  
Paul B. McCay
Keyword(s):  
Free Radical ◽  
Cardiac Ischemia ◽  
Ischemia And Reperfusion ◽  
Free Radical Generation ◽  
Radical Generation

Humic-like substances in cigarette smoke condensate and lung tissue of smokers

1994 ◽  
Vol 266 (4) ◽  
pp. L382-L388 ◽  
Author(s):  
A. J. Ghio ◽  
J. Stonehuerner ◽  
D. R. Quigley
Keyword(s):  
Free Radical ◽  
Cigarette Smoke ◽  
Lung Tissue ◽  
Cigarette Smoke Exposure ◽  
Cigarette Smoke Condensate ◽  
Free Radical Generation ◽  
Carboxylate Content ◽  
Radical Generation

Deposition of pigmented matter in the lower respiratory tract correlates with the extent of emphysema in smokers as well as with free radical generation and iron accumulation. Pulmonary emphysema is postulated to be mediated by free radical generation which is either directly or indirectly associated with cigarette smoke exposure. The hypothesis was tested that 1) incomplete combustion of tobacco yields humic-like substances (HLS) which 2) deposit in the lung as pigmented particulates, 3) complex iron cations in vitro and in vivo, and 4) have a capacity to catalyze oxidant formation. HLS, isolated by alkali extraction of cigarette smoke condensate (CSC) (Tobacco Health Research Institute, University of Kentucky), demonstrated a high carbon and low carboxylate content on elemental and functional group analyses, respectively, compared with values for HLS sequestered from soils. The HLS isolated from CSC had a capacity to complex iron in vitro and accumulated the metal in vivo after intratracheal instillation in an animal model. Both HLS and its iron complex generated free radicals, and some portion of this oxidant generation was metal dependent. Lung tissue collected at autopsy from smokers contained HLS with an infrared spectrum almost identical to that of the material isolated from CSC. Associations between particulate deposition, metal accumulation, and free radical generation suggest a possible role of HLS in the induction of lung disease following cigarette exposure.

scholarly journals Enhanced chemiluminescence as a measure of oxygen-derived free radical generation during ischemia and reperfusion.

1990 ◽  
Vol 67 (6) ◽  
pp. 1453-1461 ◽  
Author(s):  
T D Henry ◽  
S L Archer ◽  
D Nelson ◽  
E K Weir ◽  
A H From
Keyword(s):  
Free Radical ◽  
Ischemia And Reperfusion ◽  
Free Radical Generation ◽  
Enhanced Chemiluminescence ◽  
Radical Generation

scholarly journals Obesity-induced tissue free radical generation: An in vivo immuno-spin trapping study

2012 ◽  
Vol 52 (11-12) ◽  
pp. 2312-2319 ◽  
Author(s):  
Nicholas K.H. Khoo ◽  
Nadiezhda Cantu-Medellin ◽  
Jason E. Devlin ◽  
Claudette M. St. Croix ◽  
Simon C. Watkins ◽  
...  
Keyword(s):  
Free Radical ◽  
Spin Trapping ◽  
Free Radical Generation ◽  
Radical Generation
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