Bauhenia tomentosa Stimulates the Immune System and Scavenges Free-Radical Generation in vitro and in vivo

2010 ◽  
Vol 21 (2) ◽  
Author(s):  
N. Kannan ◽  
R.E. Renitta ◽  
C. Guruvayoorappan
Keyword(s):  
Immune System ◽  
Free Radical ◽  
Free Radical Generation ◽  
Radical Generation

Humic-like substances in cigarette smoke condensate and lung tissue of smokers

1994 ◽  
Vol 266 (4) ◽  
pp. L382-L388 ◽  
Author(s):  
A. J. Ghio ◽  
J. Stonehuerner ◽  
D. R. Quigley
Keyword(s):  
Free Radical ◽  
Cigarette Smoke ◽  
Lung Tissue ◽  
Cigarette Smoke Exposure ◽  
Cigarette Smoke Condensate ◽  
Free Radical Generation ◽  
Carboxylate Content ◽  
Radical Generation

Deposition of pigmented matter in the lower respiratory tract correlates with the extent of emphysema in smokers as well as with free radical generation and iron accumulation. Pulmonary emphysema is postulated to be mediated by free radical generation which is either directly or indirectly associated with cigarette smoke exposure. The hypothesis was tested that 1) incomplete combustion of tobacco yields humic-like substances (HLS) which 2) deposit in the lung as pigmented particulates, 3) complex iron cations in vitro and in vivo, and 4) have a capacity to catalyze oxidant formation. HLS, isolated by alkali extraction of cigarette smoke condensate (CSC) (Tobacco Health Research Institute, University of Kentucky), demonstrated a high carbon and low carboxylate content on elemental and functional group analyses, respectively, compared with values for HLS sequestered from soils. The HLS isolated from CSC had a capacity to complex iron in vitro and accumulated the metal in vivo after intratracheal instillation in an animal model. Both HLS and its iron complex generated free radicals, and some portion of this oxidant generation was metal dependent. Lung tissue collected at autopsy from smokers contained HLS with an infrared spectrum almost identical to that of the material isolated from CSC. Associations between particulate deposition, metal accumulation, and free radical generation suggest a possible role of HLS in the induction of lung disease following cigarette exposure.

Uptake and distribution of cis-unsaturated fatty acids and their effect on free radical generation in normal and tumor cells in vitro

1987 ◽  
Vol 3 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Undurti N. Das ◽  
Yung-S. Huang ◽  
Michel E. Bēgin ◽  
Greg Ells ◽  
David F. Horrobin
Keyword(s):  
Fatty Acids ◽  
Free Radical ◽  
Tumor Cells ◽  
Unsaturated Fatty Acids ◽  
Free Radical Generation ◽  
Radical Generation

Polyunsaturated fatty acids augment free radical generation in tumor cells in vitro

1987 ◽  
Vol 145 (1) ◽  
pp. 15-24 ◽  
Author(s):  
U.N. Das ◽  
M.E. Begin ◽  
G. Ells ◽  
Y.S. Huang ◽  
D.F. Horrobin
Keyword(s):  
Fatty Acids ◽  
Free Radical ◽  
Polyunsaturated Fatty Acids ◽  
Tumor Cells ◽  
Free Radical Generation ◽  
Radical Generation
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