Interindividual Variation in Human Chemical Carcinogenesis: Implications for Risk Assessment

1990 ◽  
pp. 235-251 ◽  
Author(s):  
Curtis C. Harris
Keyword(s):  
Risk Assessment ◽  
Chemical Carcinogenesis ◽  
Interindividual Variation

scholarly journals An Alternative Perspective: A Critical Evaluation of the Waddell Threshold Extrapolation Model in Chemical Carcinogenesis

2003 ◽  
Vol 31 (5) ◽  
pp. 468-470
Author(s):  
J.K. Haseman
Keyword(s):  
Risk Assessment ◽  
Cancer Risk ◽  
Scientific Community ◽  
Low Dose ◽  
Critical Evaluation ◽  
Chemical Carcinogenesis ◽  
Linear Extrapolation ◽  
Alternative Perspective ◽  
Extrapolation Model ◽  
Log Linear

In a recent Perspective article ( Toxicologic Pathology 31: 260—262, 2003) Waddell asserts that he has developed a log linear extrapolation model that can demonstrate a threshold and resolve for once and for all the uncertainies associated with low dose cancer risk extrapolation. However, his method essentially forces, rather than demonstrates, a threshold, and has many serious flaws that result in significant under-estimation of low dose risk. It would be a serious mistake for the scientific community to adopt Waddell's log linear extrapolation model for chemical carcinogenesis risk assessment.

Genetic vs. Nongenetic Chemical Carcinogenesis and Risk Assessment

1982 ◽  
pp. 425-438 ◽  
Author(s):  
Richard H. Reitz ◽  
Alan M. Schumann ◽  
Philip G. Watanabe ◽  
Perry J. Gehring
Keyword(s):  
Risk Assessment ◽  
Chemical Carcinogenesis

scholarly journals Implications for risk assessment of suggested nongenotoxic mechanisms of chemical carcinogenesis.

1996 ◽  
Vol 104 (suppl 1) ◽  
pp. 123-134 ◽  
Author(s):  
R L Melnick ◽  
M C Kohn ◽  
C J Portier
Keyword(s):  
Risk Assessment ◽  
Chemical Carcinogenesis
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