Immunotherapy of Spontaneously Arising Rat Mammary Tumours

1981 ◽  
pp. 185-195
Author(s):  
R. W. Baldwin ◽  
M. V. Pimm ◽  
N. Willmott
Keyword(s):  
Mammary Tumours

scholarly journals Ovarian cycle stage critically affects 21-gene recurrence scores in Mmtv-Pymt mouse mammary tumours

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sarah M. Bernhardt ◽  
Pallave Dasari ◽  
Danielle J. Glynn ◽  
Lucy Woolford ◽  
Lachlan M. Moldenhauer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Menstrual Cycle ◽  
Recurrence Score ◽  
Gene Signature ◽  
Ovarian Cycle ◽  
Oncotype Dx ◽  
Mammary Tumours ◽  
Er Positive ◽  
The Impact

Abstract Background The Oncotype DX 21-gene Recurrence Score is predictive of adjuvant chemotherapy benefit for women with early-stage, estrogen receptor (ER)-positive, HER2-negative breast cancer. In premenopausal women, fluctuations in estrogen and progesterone during the menstrual cycle impact gene expression in hormone-responsive cancers. However, the extent to which menstrual cycling affects the Oncotype DX 21-gene signature remains unclear. Here, we investigate the impact of ovarian cycle stage on the 21-gene signature using a naturally cycling mouse model of breast cancer. Methods ER-positive mammary tumours were dissected from naturally cycling Mmtv-Pymt mice at either the estrus or diestrus phase of the ovarian cycle. The Oncotype DX 21-gene signature was assessed through quantitative real time-PCR, and a 21-gene experimental recurrence score analogous to the Oncotype DX Recurrence Score was calculated. Results Tumours collected at diestrus exhibited significant differences in expression of 6 Oncotype DX signature genes (Ki67, Ccnb1, Esr1, Erbb2, Grb7, Bag1; p ≤ 0.05) and a significant increase in 21-gene recurrence score (21.8 ± 2.4; mean ± SEM) compared to tumours dissected at estrus (15.5 ± 1.9; p = 0.03). Clustering analysis revealed a subgroup of tumours collected at diestrus characterised by increased expression of proliferation- (p < 0.001) and invasion-group (p = 0.01) genes, and increased 21-gene recurrence score (p = 0.01). No correlation between ER, PR, HER2, and KI67 protein abundance measured by Western blot and abundance of mRNA for the corresponding gene was observed, suggesting that gene expression is more susceptible to hormone-induced fluctuation compared to protein expression. Conclusions Ovarian cycle stage at the time of tissue collection critically affects the 21-gene signature in Mmtv-Pymt murine mammary tumours. Further studies are required to determine whether Oncotype DX Recurrence Scores in women are similarly affected by menstrual cycle stage.

7,12-dimethylbenzanthracene induced mammary tumours in wistar rats by ‘air pouch’ technique—A new approach

1984 ◽  
Vol 25 (2) ◽  
pp. 187-194 ◽  
Author(s):  
B. Arun ◽  
M. Udayachander ◽  
A. Meenakshi
Keyword(s):  
Wistar Rats ◽  
New Approach ◽  
Air Pouch ◽  
Mammary Tumours

Prognostic studies of canine and feline mammary tumours: The need for standardized procedures

2012 ◽  
Vol 193 (1) ◽  
pp. 24-31 ◽  
Author(s):  
A.J.F. Matos ◽  
C.S. Baptista ◽  
M.F. Gärtner ◽  
G.R. Rutteman
Keyword(s):  
Mammary Tumours

PEG-coated Poly(lactic acid) Nanoparticles for the Delivery of Hexadecafluoro Zinc Phthalocyanine to EMT-6 Mouse Mammary Tumours

1995 ◽  
Vol 47 (5) ◽  
pp. 382-387 ◽  
Author(s):  
ERIC ALLEMANN ◽  
NICOLE BRASSEUR ◽  
OUHIDA BENREZZAK ◽  
JACQUES ROUSSEAU ◽  
SVETLANA V. KUDREVICH ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Zinc Phthalocyanine ◽  
Poly Lactic Acid ◽  
Mammary Tumours ◽  
Mouse Mammary Tumours

THE UPTAKE OF TRITIATED OESTRADIOL BY DIMETHYLBENZANTHRACENE-INDUCED MAMMARY TUMOURS OF THE RAT

1966 ◽  
Vol 36 (4) ◽  
pp. 409-414 ◽  
Author(s):  
B. G. MOBBS
Keyword(s):  
Mammary Tumours ◽  
Target Organs ◽  
Wet Weight ◽  
Free Steroid

SUMMARY The uptake of injected [6,7-3H]oestradiol by 9,10-dimethyl-1,2-benzanthracene-induced mammary tumours of the rat was investigated. Hormone-responsive adenomata differed from unresponsive adenomata in their ability to concentrate the hormone. The concentration of tritiated oestrogen present as free steroid in adenomata which failed to regress after ovariectomy was twice that found in muscle 20 min. after injection, and this ratio did not change significantly for 2 hr. after injection. Hormone-responsive adenomata concentrated the hormone to a much greater extent: the amount of tritiated oestrogen/mg. wet weight continued to rise for 100 min. after injection, when the concentration of radioactive steroid present in the tumours was 8–20 times that present in muscle. In this respect, the hormone-responsive tumours behaved in a similar way to the uterus and other target organs for oestrogen which have been investigated by other authors. Mixed adenomata, that is, those which contained both hormone-responsive and -unresponsive tissue, and fibroadenomata concentrated the injected oestradiol to an extent intermediate between the wholly responsive and wholly unresponsive adenomata.

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