Light Hydrocarbon-Induced Nephrotoxicity: the Interaction of 2,2,4-Trimethylpentane with Alpha-2U-Globulin in the Male Rat Kidney

1989 ◽  
pp. 527-534 ◽  
Author(s):  
E. A. Lock ◽  
M. Charbonneau ◽  
J. Strasser ◽  
J. A. Swenberg ◽  
J. S. Bus
Keyword(s):  
Rat Kidney ◽  
Light Hydrocarbon ◽  
Male Rat

Subchronic Toxicity Studies Indicate that Tris(2-Chloroethyl)Phosphate Administration Results in Lesions in the Rat Hippocampus

1990 ◽  
Vol 6 (1) ◽  
pp. 1-15 ◽  
Author(s):  
H.B. Matthews ◽  
D. Dixon ◽  
D.W. Herr ◽  
H. Tilson
Keyword(s):  
Flame Retardants ◽  
Pyramidal Neurons ◽  
Rat Kidney ◽  
Female Rats ◽  
Male Rat ◽  
Repeat Dose ◽  
Female Rat ◽  
Synthetic Fibers ◽  
Ca1 Region ◽  
Liver And Kidney

Tris(2-chloroethyl)phosphate (TRCP), a flame-retardant plasticizer used in plastics, polymeric foams and synthetic fibers, was studied as part of the National Toxicology Program's class study of phosphate flame-retardants. TRCP was administered at 0, 22, 44, 88, 175 and 350 mg/kg to both sexes of rats and 0, 44, 88, 175, 350 and 700 mg/kg to both sexes of mice in both fourteen day repeat dose and sixteen week subchronic studies. Results of these studies showed that TRCP toxicity in the 14-day studies was limited to modest increases in male rat kidney and female rat liver weights. Little evidence of toxicity was observed in mice in the 14 day studies. Toxicity observed in mice in the sixteen week studies was limited to increased liver weights in both sexes and decreased kidney weights in males. Administration of TRCP to rats for sixteen weeks resulted in increased mortality of both males and females, increased liver and kidney weights and a lesion in the hippocampal region of the brain. The lesion observed in rat brain appeared as loss of the pyramidal neurons of the CA1 region of the hippocampus and was both more common and more severe in female rats. This lesion, which was not observed in mice, is unusual for any chemical and is unique for a trialkyl phosphate such as TRCP. It is speculated that this highly directed toxicity of TRCP might be used as a chemical probe to investigate the role of the hippocampus in behavior and other functions.

356 Toxic effect of aqueous coffee extract on male rat kidney (stereological study)

2003 ◽  
Vol 144 ◽  
pp. s97
Author(s):  
M.R. Panjehshahin ◽  
F. Dehghani ◽  
R. Dezfullian
Keyword(s):  
Toxic Effect ◽  
Rat Kidney ◽  
Male Rat

The action of estrogens on the androgen-dependent microsomal activity of 3α-hydroxysteroid dehydrogenase in male rat kidney

1979 ◽  
Vol 11 (3) ◽  
pp. 1259-1264 ◽  
Author(s):  
R. Ghraf ◽  
H.-J. Deutsch ◽  
E.R. Lax ◽  
H. Schriefers
Keyword(s):  
Rat Kidney ◽  
Hydroxysteroid Dehydrogenase ◽  
Male Rat

Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney

2016 ◽  
Vol 79 (20) ◽  
pp. 905-911 ◽  
Author(s):  
Aleksandra Nikolić-Kokić ◽  
Ana Mijušković ◽  
Nikola Tatalović ◽  
Jelena Nestorov ◽  
Marko Miler ◽  
...  
Keyword(s):  
Antipsychotic Drug ◽  
Drug Administration ◽  
Rat Kidney ◽  
Male Rat ◽  
Defense Enzymes ◽  
Antioxidative Defense

The protective role of bee honey against the toxic effect of melamine in the male rat kidney

2014 ◽  
Vol 31 (6) ◽  
pp. 485-493 ◽  
Author(s):  
Madeha N Al-Seeni ◽  
Haddad A El Rabey ◽  
Suad M Al-Solamy
Keyword(s):  
Toxic Effect ◽  
Rat Kidney ◽  
Protective Role ◽  
Male Rat

Current Perspectives on Gasoline (Light Hydrocarbon)-Induced Male Rat Nephropathy

1988 ◽  
Vol 534 (1 Living in a C) ◽  
pp. 481-485 ◽  
Author(s):  
JAMES E. GIBSON ◽  
JAMES S. BUS
Keyword(s):  
Light Hydrocarbon ◽  
Male Rat
Sign in / Sign up

Export Citation Format

Share Document