The purpose of the paper is to assess the impact of the Regional Mobility and Logistic Plan (RMLP) of Tuscany on regional growth and spatial disparities between the Tuscan provinces. In order to evaluate its economic impact, we first quantify the impact in terms of changes in travel time and variations in the cost of transportation per unit of delivered output. We then make use of the Remi-Irpet model. The latter explains the agglomeration economies and productivity differentials. We find that, despite the fact that the RMLP does not solve the structural problem of mobility within Tuscany, it does make it possible to get rid of some potential constraints for long-term regional growth, even if the economic impact across the provinces is disequalizing.