Phenotyping of Gap-Junctional Coupling in the Mouse Retina

2018 ◽  
pp. 249-259 ◽  
Author(s):  
Arndt Meyer ◽  
Shubhash Chandra Yadav ◽  
Karin Dedek
Keyword(s):  
Mouse Retina ◽  
Junctional Coupling ◽  
Gap Junctional ◽  
Gap Junctional Coupling

Connexin36 mediates gap junctional coupling of alpha-ganglion cells in mouse retina

2005 ◽  
Vol 485 (3) ◽  
pp. 191-201 ◽  
Author(s):  
Timm Schubert ◽  
Joachim Degen ◽  
Klaus Willecke ◽  
Sheriar G. Hormuzdi ◽  
Hannah Monyer ◽  
...  
Keyword(s):  
Ganglion Cells ◽  
Mouse Retina ◽  
Junctional Coupling ◽  
Gap Junctional ◽  
Gap Junctional Coupling

Connexin45 mediates gap junctional coupling of bistratified ganglion cells in the mouse retina

2005 ◽  
Vol 490 (1) ◽  
pp. 29-39 ◽  
Author(s):  
Timm Schubert ◽  
Stephan Maxeiner ◽  
Olaf Krüger ◽  
Klaus Willecke ◽  
Reto Weiler
Keyword(s):  
Ganglion Cells ◽  
Mouse Retina ◽  
Junctional Coupling ◽  
Gap Junctional ◽  
Gap Junctional Coupling

scholarly journals Connexin36 is required for gap junctional coupling of most ganglion cell subtypes in the mouse retina

2010 ◽  
Vol 518 (6) ◽  
pp. 911-927 ◽  
Author(s):  
Feng Pan ◽  
David L. Paul ◽  
Stewart A. Bloomfield ◽  
Béla Völgyi
Keyword(s):  
Ganglion Cell ◽  
Mouse Retina ◽  
Junctional Coupling ◽  
Gap Junctional ◽  
Gap Junctional Coupling

Mesopic background lights enhance dark-adapted cone ERG flash responses in the intact mouse retina: a possible role for gap junctional decoupling

2011 ◽  
Vol 105 (5) ◽  
pp. 2309-2318 ◽  
Author(s):  
H. Heikkinen ◽  
F. Vinberg ◽  
S. Nymark ◽  
A. Koskelainen
Keyword(s):  
Light Adaptation ◽  
Ex Vivo ◽  
Mouse Retina ◽  
Maximal Effect ◽  
Intact Mouse ◽  
Background Light ◽  
Rods And Cones ◽  
Junctional Coupling ◽  
Gap Junctional ◽  
Gap Junctional Coupling

The cone-driven flash responses of mouse electroretinogram (ERG) increase as much as twofold over the course of several minutes during adaptation to a rod-compressing background light. The origins of this phenomenon were investigated in the present work by recording preflash-isolated (M-)cone flash responses ex vivo in darkness and during application of various steady background lights. In this protocol, the cone stimulating flash was preceded by a preflash that maintains rods under saturation (hyperpolarized) to allow selective stimulation of the cones at varying background light levels. The light-induced growth was found to represent true enhancement of cone flash responses with respect to their dark-adapted state. It developed within minutes, and its overall magnitude was a graded function of the background light intensity. The threshold intensity of cone response growth was observed with lights in the low mesopic luminance region, at which rod responses are partly compressed. Maximal effect was reached at intensities sufficient to suppress ∼90% of the rod responses. Light-induced enhancement of the cone photoresponses was not sensitive to antagonists and agonists of glutamatergic transmission. However, applying gap junction blockers to the dark-adapted retina produced qualitatively similar changes in the cone flash responses as did background light and prevented further growth during subsequent light-adaptation. These results are consistent with the idea that cone ERG photoresponses are suppressed in the dark-adapted mouse retina by gap junctional coupling between rods and cones. This coupling would then be gradually and reversibly removed by mesopic background lights, allowing larger functional range for the cone light responses.

Bursting in Inhibitory Interneuronal Networks: A Role for Gap-Junctional Coupling

1999 ◽  
Vol 81 (3) ◽  
pp. 1274-1283 ◽  
Author(s):  
F. K. Skinner ◽  
L. Zhang ◽  
J. L. Perez Velazquez ◽  
P. L. Carlen
Keyword(s):  
Theoretical Work ◽  
Oscillatory Behavior ◽  
Minimal Network ◽  
Junctional Coupling ◽  
Synchronization Mechanisms ◽  
The Individual ◽  
Gap Junctional ◽  
Gap Junctional Coupling ◽  
Inhibitory Networks

Bursting in inhibitory interneuronal networks: a role for gap-junctional coupling. Much work now emphasizes the concept that interneuronal networks play critical roles in generating synchronized, oscillatory behavior. Experimental work has shown that functional inhibitory networks alone can produce synchronized activity, and theoretical work has demonstrated how synchrony could occur in mutually inhibitory networks. Even though gap junctions are known to exist between interneurons, their role is far from clear. We present a mechanism by which synchronized bursting can be produced in a minimal network of mutually inhibitory and gap-junctionally coupled neurons. The bursting relies on the presence of persistent sodium and slowly inactivating potassium currents in the individual neurons. Both GABAA inhibitory currents and gap-junctional coupling are required for stable bursting behavior to be obtained. Typically, the role of gap-junctional coupling is focused on synchronization mechanisms. However, these results suggest that a possible role of gap-junctional coupling may lie in the generation and stabilization of bursting oscillatory behavior.

scholarly journals Short-term depression of gap junctional coupling in reticular thalamic neurons of absence epileptic rats

2016 ◽  
Vol 594 (19) ◽  
pp. 5695-5710 ◽  
Author(s):  
Denise Kohmann ◽  
Annika Lüttjohann ◽  
Thomas Seidenbecher ◽  
Philippe Coulon ◽  
Hans-Christian Pape
Keyword(s):  
Short Term ◽  
Thalamic Neurons ◽  
Junctional Coupling ◽  
Gap Junctional ◽  
Gap Junctional Coupling

Prolonged epileptiform bursting induced by 0-Mg2+ in rat hippocampal slices depends on gap junctional coupling

Neuroscience ◽  
2001 ◽  
Vol 105 (3) ◽  
pp. 579-587 ◽  
Author(s):  
R Köhling ◽  
S.J Gladwell ◽  
E Bracci ◽  
M Vreugdenhil ◽  
J.G.R Jefferys
Keyword(s):  
Hippocampal Slices ◽  
Junctional Coupling ◽  
Gap Junctional ◽  
Gap Junctional Coupling

scholarly journals Nerve Injury Induces Gap Junctional Coupling among Axotomized Adult Motor Neurons

2000 ◽  
Vol 20 (2) ◽  
pp. 674-684 ◽  
Author(s):  
Qiang Chang ◽  
Alberto Pereda ◽  
Martin J. Pinter ◽  
Rita J. Balice-Gordon
Keyword(s):  
Nerve Injury ◽  
Motor Neurons ◽  
Junctional Coupling ◽  
Gap Junctional ◽  
Gap Junctional Coupling

ATP-sensitive K+ channels (Kir6.1/SUR1) regulate gap junctional coupling in cochlear-supporting cells

2016 ◽  
Vol 468 (7) ◽  
pp. 1215-1222 ◽  
Author(s):  
Alexander Blödow ◽  
Daniela Begandt ◽  
Almke Bader ◽  
Annegret Becker ◽  
Alice Burghard ◽  
...  
Keyword(s):  
Supporting Cells ◽  
K Channels ◽  
Junctional Coupling ◽  
Cochlear Supporting Cells ◽  
Gap Junctional ◽  
Gap Junctional Coupling
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