scholarly journals Isolation and Purification of Tissue Resident Macrophages for the Analysis of Nuclear Receptor Activity

2019 ◽  
pp. 59-73 ◽  
Author(s):  
Laura Alonso-Herranz ◽  
Jesús Porcuna ◽  
Mercedes Ricote
Keyword(s):  
Nuclear Receptor ◽  
Receptor Activity ◽  
Isolation And Purification

scholarly journals Type 1 Nuclear Receptor Activity in Breast Cancer: Translating Preclinical Insights to the Clinic

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4972
Author(s):  
Sanjeev Kumar ◽  
Allegra Freelander ◽  
Elgene Lim
Keyword(s):  
Breast Cancer ◽  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Patient Outcomes ◽  
Estrogen Receptor Α ◽  
Receptor Activity ◽  
Breast Cancers ◽  
Cancer Subtypes ◽  
Major Breast

The nuclear receptor (NR) family of transcription factors is intimately associated with the development, progression and treatment of breast cancer. They are used diagnostically and prognostically, and crosstalk between nuclear receptor pathways and growth factor signalling has been demonstrated in all major subtypes of breast cancer. The majority of breast cancers are driven by estrogen receptor α (ER), and anti-estrogenic therapies remain the backbone of treatment, leading to clinically impactful improvements in patient outcomes. This serves as a blueprint for the development of therapies targeting other nuclear receptors. More recently, pivotal findings into modulating the progesterone (PR) and androgen receptors (AR), with accompanying mechanistic insights into NR crosstalk and interactions with other proliferative pathways, have led to clinical trials in all of the major breast cancer subtypes. A growing body of evidence now supports targeting other Type 1 nuclear receptors such as the glucocorticoid receptor (GR), as well as Type 2 NRs such as the vitamin D receptor (VDR). Here, we reviewed the existing preclinical insights into nuclear receptor activity in breast cancer, with a focus on Type 1 NRs. We also discussed the potential to translate these findings into improving patient outcomes.

scholarly journals Multiple Phosphorylation Events Control Chicken Ovalbumin Upstream Promoter Transcription Factor I Orphan Nuclear Receptor Activity

2002 ◽  
Vol 16 (6) ◽  
pp. 1332-1351 ◽  
Author(s):  
Frédérique Gay ◽  
Peter Baráth ◽  
Christine Desbois-Le Péron ◽  
Raphaël Métivier ◽  
Rémy Le Guével ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Nuclear Receptor ◽  
Receptor Activity ◽  
Orphan Nuclear Receptor ◽  
Factor I ◽  
Upstream Promoter ◽  
Chicken Ovalbumin

scholarly journals Dynamic regulation of Drosophila nuclear receptor activity in vivo

Development ◽  
2006 ◽  
Vol 133 (18) ◽  
pp. 3549-3562 ◽  
Author(s):  
L. Palanker
Keyword(s):  
Nuclear Receptor ◽  
Receptor Activity ◽  
Dynamic Regulation

scholarly journals Regulation of Androgen Receptor Activity by the Nuclear Receptor Corepressor SMRT

2002 ◽  
Vol 278 (7) ◽  
pp. 5052-5061 ◽  
Author(s):  
Guoqing Liao ◽  
Liuh-Yow Chen ◽  
Aihua Zhang ◽  
Aparna Godavarthy ◽  
Fang Xia ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Nuclear Receptor ◽  
Receptor Activity ◽  
Nuclear Receptor Corepressor ◽  
Androgen Receptor Activity

scholarly journals Regulation of Nuclear Receptor Activity by a Pseudouridine Synthase through Posttranscriptional Modification of Steroid Receptor RNA Activator

2004 ◽  
Vol 15 (4) ◽  
pp. 549-558 ◽  
Author(s):  
Xiansi Zhao ◽  
Jeffrey R. Patton ◽  
Shannon L. Davis ◽  
Brian Florence ◽  
Sarah J. Ames ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Steroid Receptor ◽  
Receptor Activity ◽  
Posttranscriptional Modification ◽  
Pseudouridine Synthase
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