Making Germ Cells from Human Embryonic Stem Cells

2010 ◽  
pp. 49-86
Author(s):  
Sonya M. Schuh-Huerta ◽  
Renee A. Reijo Pera
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Germ Cells ◽  
Embryonic Stem

scholarly journals A Novel Approach for the Derivation of Putative Primordial Germ Cells and Sertoli Cells from Human Embryonic Stem Cells

Stem Cells ◽  
2009 ◽  
Vol 27 (1) ◽  
pp. 68-77 ◽  
Author(s):  
Nathan Bucay ◽  
Mayra Yebra ◽  
Vincenzo Cirulli ◽  
Ivka Afrikanova ◽  
Thomas Kaido ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Germ Cells ◽  
Sertoli Cells ◽  
Primordial Germ Cells ◽  
Embryonic Stem ◽  
Novel Approach

Isolation of Primordial Germ Cells from Differentiating Human Embryonic Stem Cells

Stem Cells ◽  
2008 ◽  
Vol 26 (12) ◽  
pp. 3075-3085 ◽  
Author(s):  
Katarzyna Tilgner ◽  
Stuart P. Atkinson ◽  
Anna Golebiewska ◽  
Miodrag Stojković ◽  
Majlinda Lako ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Germ Cells ◽  
Primordial Germ Cells ◽  
Embryonic Stem

scholarly journals Germ cells from mouse and human embryonic stem cells

Reproduction ◽  
2006 ◽  
Vol 132 (5) ◽  
pp. 699-707 ◽  
Author(s):  
Behrouz Aflatoonian ◽  
Harry Moore
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Germ Cells ◽  
Primordial Germ Cells ◽  
Endocrine Disrupting Chemicals ◽  
Embryonic Stem ◽  
Founder Population ◽  
Testicular Dysgenesis Syndrome

Mammalian gametes are derived from a founder population of primordial germ cells (PGCs) that are determined early in embryogenesis and set aside for unique development. Understanding the mechanisms of PGC determination and differentiation is important for elucidating causes of infertility and how endocrine disrupting chemicals may potentially increase susceptibility to congenital reproductive abnormalities and conditions such as testicular cancer in adulthood (testicular dysgenesis syndrome). Primordial germ cells are closely related to embryonic stem cells (ESCs) and embryonic germ (EG) cells and comparisons between these cell types are providing new information about pluripotency and epigenetic processes. Murine ESCs can differentiate to PGCs, gametes and even blastocysts – recently live mouse pups were born from sperm generated from mESCs. Although investigations are still preliminary, human embryonic stem cells (hESCs) apparently display a similar developmental capacity to generate PGCs and immature gametes. Exactly how such gamete-like cells are generated during stem cell culture remains unclear especially as in vitro conditions are ill-defined. The findings are discussed in relation to the mechanisms of human PGC and gamete development and the biotechnology of hESCs and hEG cells.

Differentiation of Germ Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells.Renee A. Reijo Pera, Ph.D.

2009 ◽  
Vol 81 (Suppl_1) ◽  
pp. 117-117
Author(s):  
Renee Ann Reijo Pera ◽  
Kehkooi Kee ◽  
Vanessa T. Angeles ◽  
Marty Flores
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Germ Cells ◽  
Embryonic Stem ◽  
Induced Pluripotent

scholarly journals CHIR99021 combined with retinoic acid promotes the differentiation of primordial germ cells from human embryonic stem cells

Oncotarget ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 7814-7826 ◽  
Author(s):  
Tingting Cheng ◽  
Kui Zhai ◽  
Yan Chang ◽  
Guidong Yao ◽  
Jiahuan He ◽  
...  
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Germ Cells ◽  
Primordial Germ Cells ◽  
Embryonic Stem

scholarly journals Granulosa cells and retinoic acid co-treatment enrich potential germ cells from manually selected Oct4-EGFP expressing human embryonic stem cells

2014 ◽  
Vol 29 (3) ◽  
pp. 319-332 ◽  
Author(s):  
Hsin-Fu Chen ◽  
Pey-Shynan Jan ◽  
Hung-Chih Kuo ◽  
Fang-Chun Wu ◽  
Chen-Wei Lan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Retinoic Acid ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Germ Cells ◽  
Granulosa Cells ◽  
Embryonic Stem
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