The Use of JAK-Specific Inhibitors as Chemical Biology Tools

2012 ◽  
pp. 99-113 ◽  
Author(s):  
Christopher J. Burns ◽  
David Segal ◽  
Andrew F. Wilks
Keyword(s):  
Chemical Biology ◽  
Specific Inhibitors

Correction: Graduate Education in Chemical Biology at the University of Michigan

2006 ◽  
Vol 1 (9) ◽  
pp. 601
Author(s):  
Tonia J. Buchholz ◽  
Bruce Palfey ◽  
Anna K. Mapp ◽  
Gary D. Glick
Keyword(s):  
Graduate Education ◽  
Chemical Biology ◽  
University Of Michigan ◽  
The University

Chemical biology: A natural painkiller

Nature China ◽  
2014 ◽  
Author(s):  
Felix Cheung
Keyword(s):  
Chemical Biology

Chemical biology: On neutral ground

Nature China ◽  
2009 ◽  
Author(s):  
Felix Cheung
Keyword(s):  
Chemical Biology ◽  
Neutral Ground

Partial Purification of a Specific Plasminogen Activator from Porcine Parotid Glands

1974 ◽  
Vol 31 (03) ◽  
pp. 403-414 ◽  
Author(s):  
Terence Cartwright
Keyword(s):  
Nucleic Acid ◽  
Salivary Glands ◽  
Plasminogen Activator ◽  
Protein Interactions ◽  
Partial Purification ◽  
Protein Protein Interactions ◽  
Parotid Glands ◽  
Two Stage ◽  
Preliminary Characterization ◽  
Specific Inhibitors

SummaryA method is described for the extraction with buffers of near physiological pH of a plasminogen activator from porcine salivary glands. Substantial purification of the activator was achieved although this was to some extent complicated by concomitant extraction of nucleic acid from the glands. Preliminary characterization experiments using specific inhibitors suggested that the activator functioned by a similar mechanism to that proposed for urokinase, but with some important kinetic differences in two-stage assay systems. The lack of reactivity of the pig gland enzyme in these systems might be related to the tendency to protein-protein interactions observed with this material.

Sign in / Sign up

Export Citation Format

Share Document