A High-Throughput siRNA Screening Platform to Identify MYC-Synthetic Lethal Genes as Candidate Therapeutic Targets

2013 ◽  
pp. 187-200 ◽  
Author(s):  
Carla Grandori
Keyword(s):  
High Throughput ◽  
Therapeutic Targets ◽  
Synthetic Lethal ◽  
Screening Platform ◽  
Synthetic Lethal Genes ◽  
Lethal Genes ◽  
Sirna Screening

Integrated Genomic and Pharmacological Approaches to Identify Synthetic Lethal Genes as Cancer Therapeutic Targets

2008 ◽  
Vol 8 (8) ◽  
pp. 774-783 ◽  
Author(s):  
Shinji Mizuarai ◽  
Hiroki Irie ◽  
Dennis Schmatz ◽  
Hidehito Kotani
Keyword(s):  
Therapeutic Targets ◽  
Synthetic Lethal ◽  
Synthetic Lethal Genes ◽  
Lethal Genes

Abstract 1275: Identification of cancer-specific synthetic lethal genes as novel therapeutic targets

2020 ◽  
Author(s):  
Lalchung Nunga ◽  
Ed Schwalbe ◽  
Fadhel Lafta ◽  
Deborah Tweddle ◽  
John Maris ◽  
...  
Keyword(s):  
Therapeutic Targets ◽  
Synthetic Lethal ◽  
Synthetic Lethal Genes ◽  
Novel Therapeutic ◽  
Lethal Genes

Abstract 2956: High throughput RNAi screening of synthetic lethal genes interacting with the commonTP53mutation R175H

2012 ◽  
Author(s):  
Hiroo Imai ◽  
Shunsuke Kato ◽  
Yasuhiro Sakamoto ◽  
Yuichi Kakudo ◽  
Shin Takahashi ◽  
...  
Keyword(s):  
High Throughput ◽  
Synthetic Lethal ◽  
Rnai Screening ◽  
Synthetic Lethal Genes ◽  
Lethal Genes

Abstract 1132: Identification of synthetic lethal genes to MYCN-amplified neuroblastoma.

2013 ◽  
Author(s):  
Shuobo Zhang ◽  
J Yu ◽  
N Wei ◽  
J Silva ◽  
J J. Kandel ◽  
...  
Keyword(s):  
Synthetic Lethal ◽  
Synthetic Lethal Genes ◽  
Lethal Genes

Identification and validation of vesicant therapeutic targets using a high-throughput siRNA screening approach

2014 ◽  
Vol 90 (2) ◽  
pp. 375-383
Author(s):  
Albert L. Ruff ◽  
Sarah Beach ◽  
John Lehman ◽  
Cristin Rothwell ◽  
James F. Dillman
Keyword(s):  
High Throughput ◽  
Therapeutic Targets ◽  
Screening Approach ◽  
Sirna Screening

scholarly journals Epigenetic synthetic lethality approaches in cancer therapy

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Haoshen Yang ◽  
Wei Cui ◽  
Lihui Wang
Keyword(s):  
Fusion Proteins ◽  
High Throughput Screening ◽  
Malignant Tumors ◽  
Synthetic Lethality ◽  
Parp Inhibitor ◽  
Synthetic Lethal ◽  
Epigenetic Regulators ◽  
Mutation Research ◽  
Synthetic Lethal Genes ◽  
Lethal Genes

Abstract The onset and development of malignant tumors are closely related to epigenetic modifications, and this has become a research hotspot. In recent years, a variety of epigenetic regulators have been discovered, and corresponding small molecule inhibitors have been developed, but their efficacy in solid tumors is generally poor. With the introduction of the first synthetic lethal drug (the PARP inhibitor olaparib in ovarian cancer with BRCA1 mutation), research into synthetic lethality has also become a hotspot. High-throughput screening with CRISPR-Cas9 and shRNA technology has revealed a large number of synthetic lethal pairs involving epigenetic-related synthetic lethal genes, such as those encoding SWI/SNF complex subunits, PRC2 complex subunits, SETD2, KMT2C, and MLL fusion proteins. In this review, we focus on epigenetic-related synthetic lethal mechanisms, including synthetic lethality between epigenetic mutations and epigenetic inhibitors, epigenetic mutations and non-epigenetic inhibitors, and oncogene mutations and epigenetic inhibitors.

High-Throughput Screening Platform for Nanoparticle-Mediated Alterations of DNA Repair Capacity

ACS Nano ◽  
2021 ◽  
Author(s):  
Sneh M. Toprani ◽  
Dimitrios Bitounis ◽  
Qiansheng Huang ◽  
Nathalia Oliveira ◽  
Kee Woei Ng ◽  
...  
Keyword(s):  
Dna Repair ◽  
High Throughput ◽  
High Throughput Screening ◽  
Repair Capacity ◽  
Dna Repair Capacity ◽  
Screening Platform

Time-Resolved Luminescent High-Throughput Screening Platform for Lysosomotropic Compounds in Living Cells

ACS Sensors ◽  
2020 ◽  
Author(s):  
Ke-Jia Wu ◽  
Chun Wu ◽  
Feng Chen ◽  
Sha-Sha Cheng ◽  
Dik-Lung Ma ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Living Cells ◽  
Time Resolved ◽  
Screening Platform
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