Design, Development and Initial Validation of a Wearable Particulate Matter Monitoring Solution

Stability of Anidulafungin in Concentrated Pharmaceutical Solution

Open Forum Infectious Diseases ◽

10.1093/ofid/ofx163.797 ◽

2017 ◽

Vol 4 (suppl_1) ◽

pp. S335-S336

Author(s):

Chien Yap ◽

Chi Lui Ho ◽

Yin Shan Lim ◽

Siang Fei Yeoh

Keyword(s):

Particulate Matter ◽

Normal Saline ◽

Preparation Method ◽

Package Insert ◽

Central Line ◽

Fluid Restriction ◽

Sterile Water ◽

Infusion Solution ◽

Initial Validation ◽

The Stability

Abstract Background Currently, the reconstitution instructions in the package insert indicate that 100 mg of anidulafungin powder is to be dissolved in 30 ml of sterile water for injection and this reconstituted solution is to be further mixed with 100 ml of either normal saline (NS) or dextrose 5% (w/v) (D5) to give a final infusion solution of concentration 0.77 mg/mL. The compatibility of the reconstituted solution with diluents other than NS or D5 has not been established and there is no literature to support the the use of a more concentrated infusion solution. Thus, the infusion solution prepared strictly according to the method described by the manufacturer may pose a problem clinically in patients who are indicated for treatment with anidulafungin but require fluid restriction. In order to meet the needs of the abovementioned patient populations in the clinical setting, it is imperative to establish the stability of suitable anidulafungin infusion solutions prepared in diluents that are appropriate to the patients but differ from that set forth by the manufacturer Methods After an initial validation of the HPLC-MS/MS method, the concentration of the anidulafungin solutions was determined over 48/72 hours. Other parameters assessed were pH, osmolality and particulate matter. Results 100 mg of anidulafungin powder was soluble in 15 ml of sterile water and this reconstituted solution was stable for at least 24 hours at 25. Anidulafungin infusion solutions of concentration 2 mg/mL prepared using diluents like NS, D5, half normal saline (HNS) and NSD5 were stable for at least 72 hours at 25. If the diluent was HNSD5, the infusion solution of concentration 2 mg/mL was stable for at least 48 hours at 25. All of the anidulafungin solutions tested were of acceptable standard for an injection in terms of pH, osmolality and particulate matter Conclusion The method of preparation employed yielded anidulafungin solutions of suitable stability for clinical use and can be adopted should there be a need to differ from the manufacturer’s recommended preparation method. We may use these concentrated preparations for patient with central line like in ICU or OPAT setting Disclosures All authors: No reported disclosures.

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PENGEMBANGAN MODUL MATA KULIAH STATISTIKA BERBASIS SPREADSHEET UNTUK JURUSAN AKUNTANSI POLITEKNIK

Jurnal Teknodik ◽

10.32550/teknodik.v19i2.158 ◽

2015 ◽

pp. 173-182

Author(s):

I Made Wijana ◽

A. A. Putri Suardani

Keyword(s):

Time Series ◽

Central Tendency ◽

Design Development ◽

Module Design ◽

Initial Validation ◽

Need Analysis ◽

Statistics Course ◽

Basic Competencies ◽

The One ◽

Data Frequency

Abstrak:Tujuan dari penelitian ini adalah untuk menghasilkan rancangan modul mata kuliah statistika berbasis spreadsheet yang inovatif untuk meningkatkan prestasi mahasiswa Jurusan Akuntansi pada Politeknik Negeri Bali (PNB). Metode pengembangan yang digunakan adalah model dari Direktorat Pendidikan Menengah Kejuruan yang dimodifikasi dan dirancang dalam tiga tahapan, yaitu tahap analisis kurikulum, tahap analisis kebutuhan, serta pengembangan rancangan modul-modul dan penyusunan draft modul sebelum dilakukan validasi awal. Berdasarkan analisis kurikulum dan analisis kebutuhan, maka dikembangkan 7 rancangan modul dengan judul Data, Distribusi Frekuensi, Ukuran Pemusatan, Ukuran Dispersi, Regresi dan Korelasi, Time Series, dan Angka Indeks. Rancangan modul-modul mata kuliah statistika berbasis spreadsheet dimulai dari Standar Kompetensi (SK). Kemudian, Standar Kompetensi dijabarkan menjadi beberapa Kompetensi Dasar (KD) yang masing-masing mempunyai Indikator Hasil Belajar (IHB). Selanjutnya adalah pengembangan Materi Pokok untuk mencapai Kompetensi Dasar sesuai Indikator Hasil Belajar masing-masing yang dibuat dalam bentuk modul. Masing-masing rancangan modul mengandung tujuan, kedudukan modul, isi modul serta evaluasi. Isi modul mengandung aplikasi pada spreadsheet, tugas, tes formatif dan tes kompetensi.Kata kunci: Statistika, Modul, Modul Berbasis SpreadsheetAbstract:The purpose of this research was to produce a design of innovative spreadsheet-based statistics course modules to enhance the achievement of students of Accounting Department of Bali State Polytechnic (PNB). The applied method was the one from the Directorate of Vocational Middle Education which was modified and designed in three steps, namely Curriculum Analysis, Need Analysis, and Module Design Development as well as Module Draft Arrangement before initial validation. Based on the curriculum and need analysis, 7 modules are designed: Data, Frequency Distribution, Central Tendency, Dispersion, Regression and Correlation, Time Series, and Index. Spreadsheet-based statistics course module design starts from Competence Standard (SK). Then, it is defined in some Basic Competencies (KD), of which each has their Learning Result Indicators (IHB). Each Basic Competence (KD) is developed into Principal Materials in accordance with their Learning Result Indicators in the form of module. Each modul design has its own objectives, modul position, module content, and evaluation. The module contains applications on spreadsheet, assignments, formative tests, and competency tests.Key Words: Statistics, Module, Spreadsheet-Based Modules

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777 Exposure of spontaneous hypertensive rats to ambient particulate matter affects cardiovascular performance in a Langendorff model

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(03)90512-1 ◽

2003 ◽

Vol 2 (1) ◽

pp. 168-169

Author(s):

J MEIRING ◽

K BAGATE ◽

M GERLOFSNIJLAND ◽

F CASSEE ◽

P BORM

Keyword(s):

Particulate Matter ◽

Ambient Particulate Matter ◽

Hypertensive Rats ◽

Cardiovascular Performance

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Letters. Inhalable particulate matter

Environmental Science & Technology ◽

10.1021/es00098a612 ◽

1982 ◽

Vol 16 (4) ◽

pp. 208-208

Author(s):

Bernard Goldstein

Keyword(s):

Particulate Matter ◽

Inhalable Particulate Matter

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The Difficulties in Emotion Regulation Scale (DERS)

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000093 ◽

2013 ◽

Vol 72 (1) ◽

pp. 5-11 ◽

Cited By ~ 29

Author(s):

Elise S. Dan-Glauser ◽

Klaus R. Scherer

Keyword(s):

Emotion Regulation ◽

Well Being ◽

French Translation ◽

French Version ◽

Inappropriate Behaviors ◽

Initial Validation ◽

Difficulties In Emotion Regulation ◽

Instrument Measuring ◽

Highly Correlated ◽

Psychopathological Disorders

Successful emotion regulation is a key aspect of efficient social functioning and personal well-being. Difficulties in emotion regulation lead to relationship impairments and are presumed to be involved in the onset and maintenance of some psychopathological disorders as well as inappropriate behaviors. Gratz and Roemer (2004 ) developed the Difficulties in Emotion Regulation Scale (DERS), a comprehensive instrument measuring emotion regulation problems that encompasses several dimensions on which difficulties can occur. The aim of the present work was to develop a French translation of this scale and to provide an initial validation of this instrument. The French version was created using translation and backtranslation procedures and was tested on 455 healthy students. Congruence between the original and the translated scales was .98 (Tucker’s phi) and internal consistency of the translation reached .92 (Cronbach’s α). Moreover, test-retest scores were highly correlated. Altogether, the initial validation of the French version of the DERS (DERS-F) offers satisfactory results and permits the use of this instrument to map difficulties in emotion regulation in both clinical and research contexts.

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