What Next for Experimental Economics? Searching for an Alternative Pathway Founded on Mathematical Methods

2020 ◽  
pp. 36-44
Author(s):  
Carmen Pagliari ◽  
Edgardo Bucciarelli
Keyword(s):  
Experimental Economics ◽  
Alternative Pathway ◽  
Mathematical Methods

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease

2002 ◽  
Vol 38 ◽  
pp. 37-49 ◽  
Author(s):  
Janelle Nunan ◽  
David H Small
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Alternative Pathway ◽  
Protein A ◽  
Proteolytic Processing ◽  
Gamma Secretase ◽  
Amyloid Beta Protein ◽  
Protein Precursor ◽  
Amyloid Beta Protein Precursor

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's disease. The alternative pathway, involving alpha-secretase, precludes amyloid-beta protein formation. In this review, we describe the progress that has been made in identifying the secretases and their potential as therapeutic targets in the treatment or prevention of Alzheimer's disease.

Does the alternative pathway ameliorate chilling injury in sensitive plant tissues?

1993 ◽  
Vol 88 (4) ◽  
pp. 712-718 ◽  
Author(s):  
Albert C. Purvis ◽  
Robert L. Shewfelt
Keyword(s):  
Alternative Pathway ◽  
Chilling Injury ◽  
Plant Tissues

Mathematical Formalism and Political-Economic Content

2012 ◽  
pp. 82-95 ◽  
Author(s):  
D. Foley
Keyword(s):  
Political Economy ◽  
Statistical Methods ◽  
Complex Adaptive System ◽  
Economic Modeling ◽  
Qualitative Properties ◽  
Mathematical Methods ◽  
Econometric Methods ◽  
Statistical Fluctuations ◽  
Complex Adaptive ◽  
New Thinking

Mathematical methods are only one moment in a layered process of theory generation in political economy, which starts from Schumpeterian vision, progresses to the identification of relevant abstractions, the development of mathematical and quantitative models, and the confrontation of theories with empirical data through statistical methods. But today the relevant abstract problems of political economy are modified to fit available mathematical tools. The role of empirical research in disciplining theoretical speculation, on which the scientific traditions integrity rests, was undermined by specific limitations of nascent econometric methods, and usurped by ex cathedra methodological fiats of theorists. These developmentssystematically favored certain ideological predispositions of economicsas a discipline. There is abundant room for New Thinking in political economy starting from the vision of the capitalist economy as a complex, adaptive system far from equilibrium, including the development of the theory of statistical fluctuations for economic interactions, redirection of macroeconomics and financial economics from path prediction toward an understanding of the qualitative properties of the system, introduction of constructive and computable methods into economic modeling, and the critical reconstruction of econometric statistical methods.

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