Neoadjuvant and Adjuvant Radiotherapy in Operable Pancreatic Cancer

2021 ◽  
pp. 713-728
Author(s):  
Sylvia S. W. Ng ◽  
Albert C. Koong ◽  
Natalie G. Coburn
Keyword(s):  
Pancreatic Cancer ◽  
Adjuvant Radiotherapy

scholarly journals The Role of Radiotherapy for Pancreatic Malignancies- A Population-based Analysis of the SEER-Medicare Database.

2020 ◽  
Author(s):  
yunxiu luo ◽  
Shengjun Xiao
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Carcinoma ◽  
Adjuvant Radiotherapy ◽  
Adenosquamous Carcinoma ◽  
Early Stage ◽  
Pancreatic Head ◽  
Population Based ◽  
Anatomical Location ◽  
Duct Carcinoma

Abstract Background and objective. To investigate the role of adjuvant radiotherapy in patients after surgical resection for pancreatic cancer. Methods and patients. The patients with pancreatic cancer from 18 registered institutions in the Surveillance Epidemiology and End Results (SEER) database were retrospectively analyzed. The characteristics of patients who would benefit from adjuvant radiotherapy were screened, as well as whether neoadjuvant or adjuvant radiotherapy conferred to a better clinical outcome. Results. 30249 patients included in this study (21295 vs 8954 in surgery and adjuvant radiotherapy group) .The median survivals in the surgery (S) group and adjuvant radiotherapy (S+R) group were 24 and 21 months respectively, The 1, 3, and 5-year overall survival (OS) rates in the S group and S+R group were 68%, 40%, 31% ,and 75%, 30%, 20%, respectively (p<0.001).Stratified analysis showed patients with histological classified as adenocarcinoma(15 VS 21, P<0.0001), infiltrating duct carcinoma (17 VS 21,P<0.0001), adenosquamous carcinoma(10 VS 18,P<0.0001) could be benefit from adjuvant radiotherapy. Adjuvant radiotherapy was helpful to improve the OS for patients with pancreatic head (19 VS 21, P=0.0003) and duct carcinoma (18VS 28, P=0.0121). Subgroup stratified assay indicated specific patients with early stage (AJCC 7th I, II, T2, N0) pancreatic carcinoma had better OS after additional radiotherapy than surgery alone. Conclusion. Additional radiotherapy may contribute to improved prognosis for patients with pancreatic carcinoma of specific histological types (adenocarcinoma/carcinoma, infiltrating duct carcinoma, adenosquamous carcinoma, and squamous), anatomical location, and advanced stage. A specific subgroup of patients with an early stage (I/II, T2) pancreatic cancer should be considered for additional radiotherapy.

scholarly journals Pancreatic Cancer: Adjuvant radiotherapy and chemotherapy for biliary and pancreatic cancer

1994 ◽  
Vol 5 ◽  
pp. S75-S80 ◽  
Author(s):  
T.A. Rich ◽  
D.B. Evans ◽  
S.A. Curley ◽  
J.A. Ajani
Keyword(s):  
Pancreatic Cancer ◽  
Adjuvant Radiotherapy

scholarly journals Pancreatic cancer adjuvant radiotherapy target volume design: based on the postoperative local recurrence spatial location

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Wei Yu ◽  
Wei Hu ◽  
Yongjie Shui ◽  
Xiaoyang Zhu ◽  
Chao Li ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Local Recurrence ◽  
Adjuvant Radiotherapy ◽  
Spatial Location ◽  
Target Volume

A new delineation method research of the clinical target volume for pancreatic cancer adjuvant radiotherapy

2019 ◽  
Vol 23 (3) ◽  
pp. 201-208 ◽  
Author(s):  
T.T. Zhang ◽  
L. Wei ◽  
G.W. Yuan ◽  
D.Q. Zhao ◽  
M.L. Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Adjuvant Radiotherapy ◽  
Clinical Target Volume ◽  
Target Volume

Margin Clearance and Outcome in Resected Pancreatic Cancer

2009 ◽  
Vol 27 (17) ◽  
pp. 2855-2862 ◽  
Author(s):  
David K. Chang ◽  
Amber L. Johns ◽  
Neil D. Merrett ◽  
Anthony J. Gill ◽  
Emily K. Colvin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Clinical Trials ◽  
Adjuvant Radiotherapy ◽  
Resection Margin ◽  
Resection Margins ◽  
Term Survival ◽  
Long Term Survival ◽  
Operative Resection ◽  
Occult Metastatic Disease

Purpose Current adjuvant therapies for pancreatic cancer (PC) are inconsistently used and only modestly effective. Because a high proportion of patients who undergo resection for PC likely harbor occult metastatic disease, any adjuvant trials assessing therapies such as radiotherapy directed at locoregional disease are significantly underpowered. Stratification based on the probability (and volume) of residual locoregional disease could play an important role in the design of future clinical trials assessing adjuvant radiotherapy. Patients and Methods We assessed the relationships between margin involvement, the proximity to operative resection margins and outcome in a cohort of 365 patients who underwent operative resection for PC. Results Microscopic involvement of a resection margin by tumor was associated with a poor prognosis. Stratifying the minimum clearance of resection margins by 0.5-mm increments demonstrated that although median survival was no different to clear margins based on these definitions, it was not until the resection margin was clear by more than 1.5 mm that optimal long-term survival was achieved. Conclusion These data demonstrate that a margin clearance of more than 1.5 mm is important for long-term survival in a subgroup of patients. More aggressive therapeutic approaches that target locoregional disease such as radiotherapy may be beneficial in patients with close surgical margins. Stratification of patients for entry onto future clinical trials based on this criterion may identify those patients who benefit from adjuvant radiotherapy.

Role of Adjuvant Radiotherapy in Left-Sided Pancreatic Cancer—Population-Based Analysis with Propensity Score Matching

2015 ◽  
Vol 19 (12) ◽  
pp. 2183-2191 ◽  
Author(s):  
Yu Jin Lim ◽  
Kyubo Kim ◽  
Eui Kyu Chie ◽  
BoKyong Kim ◽  
Sung W. Ha
Keyword(s):  
Pancreatic Cancer ◽  
Propensity Score ◽  
Propensity Score Matching ◽  
Adjuvant Radiotherapy ◽  
Population Based

scholarly journals Adjuvant radiotherapy and lymph node dissection in pancreatic cancer treated with surgery and chemotherapy

Cancer ◽  
2014 ◽  
Vol 120 (8) ◽  
pp. 1171-1177 ◽  
Author(s):  
Eric A. Mellon ◽  
Gregory M. Springett ◽  
Sarah E. Hoffe ◽  
Pamela Hodul ◽  
Mokenge P. Malafa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Lymph Node ◽  
Lymph Node Dissection ◽  
Adjuvant Radiotherapy ◽  
Node Dissection
Sign in / Sign up

Export Citation Format

Share Document