Relating Interfacial Shear and Dilatational Stresses to Protein Aggregation in mAbs

Author(s):  
Coleman Vaclaw ◽  
Valerie Pringle ◽  
Aishik Chakraborty ◽  
Prajnaparamita Dhar
2013 ◽  
Vol 102 (8) ◽  
pp. 2460-2470 ◽  
Author(s):  
Lu Liu ◽  
Wei Qi ◽  
Daniel K. Schwartz ◽  
Theodore W. Randolph ◽  
John F. Carpenter

Author(s):  
James R. Gaylor ◽  
Fredda Schafer ◽  
Robert E. Nordquist

Several theories on the origin of the melanosome exist. These include the Golgi origin theory, in which a tyrosinase-rich protein is "packaged" by the Golgi apparatus, thus forming the early form of the melanosome. A second theory postulates a mitochondrial origin of melanosomes. Its author contends that the melanosome is a modified mitochondria which acquires melanin during its development. A third theory states that a pre-melanosome is formed in the smooth or rough endoplasmic reticulum. Protein aggregation is suggested by one author as a possible source of the melanosome. This fourth theory postulates that the melanosome originates when the protein products of several genetic loci aggregate in the cytoplasm of the melanocyte. It is this protein matrix on which the melanin is deposited. It was with these theories in mind that this project was undertaken.


2004 ◽  
Vol 31 (S 1) ◽  
Author(s):  
R Krüger ◽  
FP Marx ◽  
D Berg ◽  
C Holzmann ◽  
T Müller ◽  
...  

1990 ◽  
Vol 18 (1) ◽  
pp. 13-65 ◽  
Author(s):  
W. W. Klingbeil ◽  
H. W. H. Witt

Abstract A three-component model for a belted radial tire, previously developed by the authors for free rolling without slip, is generalized to include longitudinal forces and deformations associated with driving and braking. Surface tractions at the tire-road interface are governed by a Coulomb friction law in which the coefficient of friction is assumed to be constant. After a brief review of the model, the mechanism of interfacial shear force generation is delineated and explored under traction with perfect adhesion. Addition of the friction law then leads to the inception of slide zones, which propagate through the footprint with increasing severity of maneuvers. Different behavior patterns under driving and braking are emphasized, with comparisons being given of sliding displacements, sliding velocities, and frictional work at the tire-road interface. As a further application of the model, the effect of friction coefficient and of test variables such as load, deflection, and inflation pressure on braking stiffness are computed and compared to analogous predictions on the braking spring rate.


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