Prostaglandin-Endoperoxide H Synthases (PGHSs)

2021 ◽  
pp. 1272-1272
Keyword(s):  
Prostaglandin Endoperoxide

scholarly journals Prostaglandin-Endoperoxides and Cyclic 3′-5′-AMP in Platelets of Patients with Uremia

1977 ◽  
Author(s):  
F. R. Matthias ◽  
W. Palinski
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Adenylate Cyclase ◽  
Prostaglandin E1 ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Bleeding Tendency ◽  
Prostaglandin Endoperoxide ◽  
Uremic Patients

In platelets of normal donors and of patients with chronic renal failure the following determinations were performed: 1. prostaglandin-endoperoxide-formation after N-ethylmaleimide stimulation measured as malondialdehyde; 2. the c-AMP level according to the Gilman-method; 3. the adenylate-cyclase activity in response to prostaglandin E1; 4. aggregation in response to collagen.In comparison to’normal donores the prostaglandin-endoperoxide production was reduced in uremic patients. Plasma of uremics depresses the endoperoxide formation of normal platelets. The basal c-AMP level of platelets of’ patients with renal failure was not significantly changed, whereas the plasma c-AMP level was increased; the activation of the platelets adenylate-cyclase was impaired. The adenylate-cyclase activity of platelets from normal donors was reduced by uremic plasma.. The results are of interest as to the explanation of the bleeding tendency of uremic patients.

scholarly journals Growth Factor Regulation of Prostaglandin-Endoperoxide Synthase 2 (Ptgs2) Expression in Colonic Mesenchymal Stem Cells

2009 ◽  
Vol 285 (7) ◽  
pp. 5026-5039 ◽  
Author(s):  
Monica R. Walker ◽  
Sarah L. Brown ◽  
Terrence E. Riehl ◽  
William F. Stenson ◽  
Thaddeus S. Stappenbeck
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Prostaglandin Endoperoxide ◽  
Prostaglandin Endoperoxide Synthase ◽  
Growth Factor Regulation
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