Personal healthcare enables prevention and early diagnosis in daily life and is centered on the patient. There is a need for a new personal healthcare paradigm in the treatment of chronic diseases. This will be achieved by new technologies that are currently explored (e.g., in European Research projects such as MyHeart and HeartCycle). These projects develop technologies and application concepts for the (self-)management of chronic diseases in patients’ homes with special emphasis on usability and ease-of-use (e.g., wearable sensors and processing units that can even be integrated into the patient’s clothes). These technologies allow empowering patients, fostering self-management and therefore reducing cost, and improving patients’ quality of life.