According to the similar characteristics of structure, geometry and constraints conditions in the same type of extrusion process, the intelligent design system of a square tube aluminum profile extrusion forming process was established in this paper based on the VB programming language, with using parametric programming language APDL provides by ANSYS software. The parameterized optimization design plan of pre-treatment and post-processing of ANSYS analysis during a square tube aluminum extrusion forming process was achieved, and the program of a three-dimensional model of the extrusion die under Visual Lisp environment was also programmed. The human-computer interaction intelligent design system which combined with pre-processing of semi-finished product, finite element analysis of extrusion die strength, extrusion die temperature field analysis, structural optimization of the die was realized. The research results show that the system can provide program decision-making, structural design, performance analysis and graphics treatment for the actual extrusion productions of square tube aluminum extrusion process, which reduced the design time of the technical staff, and saved design cost.