Mechanosensitive Nonselective Cation Channels in the Antiluminal Membrane of Cerebral Capillaries (Blood-Brain Barrier)

1993 ◽  
pp. 101-105 ◽  
Author(s):  
R. Popp ◽  
J. Hoyer ◽  
H. Gögelein
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Cation Channels ◽  
Cerebral Capillaries ◽  
Nonselective Cation Channels ◽  
Blood Brain

Morphological Alterations of the Blood-Brain Barrier in Experimental Serum Sickness (ESS)

1976 ◽  
Vol 34 ◽  
pp. 94-95
Author(s):  
Davis Donald A. ◽  
Milhorat Thomas H.
Keyword(s):  
Blood Brain Barrier ◽  
Serum Sickness ◽  
Brain Barrier ◽  
Periventricular White Matter ◽  
Tissue Samples ◽  
Morphological Alterations ◽  
Cerebral Capillaries ◽  
Blood Brain ◽  
Male Wistar Rats ◽  
The One

Information concerning the effects of systemic diseases on the blood-brain barrier is limited. Lampert and Carpenter (1) and Lampert et al. (2) have shown that experimental lead encephalalopathy produces a toxic vasculitis which permits intravascularly injected thorotrast to escape from cerebral capillaries into the perivascular and extracellular spaces. Other experiments (summarized in 3) have demonstrated an increased permeability of cerebral capillaries as a consequence of cerebral trauma, chemically induced vasculitis, hypertension, and radiation.Acute serum sickness was produced in adult male Wistar rats according to the “one shot” technique of Kniker and Cochrane (4). After seven to eight days the animals were decapitated and tissue samples from the cerebral cortex and periventricular white matter were quickly excised and placed in vials for prefixation in 1% depolymerized paraformaldehyde and 31 purified glutaraldehyde in 0.1M phosphate buffer (pH 7.5) for 24 hours at 4C.

Conformationally Constrained Peptide Drugs Targeted at the Blood-Brain Barrier

1995 ◽  
Author(s):  
Thomas P. Davis ◽  
Thomas J. Abbruscato ◽  
Elizabeth Brownson ◽  
Victor J. Hruby
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Peptide Drugs ◽  
Conformationally Constrained ◽  
Blood Brain
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