Eosinophilic fasciitis (Shulman’s Syndrome)

2009 ◽  
pp. 61-61
Keyword(s):  
Eosinophilic Fasciitis

A Case of Eosinophilic Fasciitis with Contracture of the Finger Joints.

1999 ◽  
Vol 61 (2) ◽  
pp. 134-137
Author(s):  
Kiho KIYOI ◽  
Tamano MATSUI ◽  
Kiyofumi EGAWA ◽  
Tomomichi ONO
Keyword(s):  
Eosinophilic Fasciitis ◽  
Finger Joints

Eosinophilic fasciitis associated with hypereosinophilia, abnormal bone-marrow karyotype and inversion of chromosome 5

2013 ◽  
Vol 39 (2) ◽  
pp. 150-153 ◽  
Author(s):  
J. S. Ferguson ◽  
J. Bosworth ◽  
T. Min ◽  
J. Mercieca ◽  
C. A. Holden
Keyword(s):  
Bone Marrow ◽  
Eosinophilic Fasciitis ◽  
Chromosome 5 ◽  
Abnormal Bone Marrow ◽  
And Inversion

Refractory eosinophilic fasciitis successfully treated with infliximab: A case report

2021 ◽  
pp. 239719832110043
Author(s):  
Paulina Śmigielska ◽  
Justyna Czarny ◽  
Jacek Kowalski ◽  
Aleksandra Wilkowska ◽  
Roman J. Nowicki
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Treatment Failure ◽  
Immunosuppressive Drugs ◽  
Unknown Etiology ◽  
High Dose ◽  
Eosinophilic Fasciitis ◽  
Line Treatment ◽  
First Line ◽  
First Line Treatment

Eosinophilic fasciitis is a rare connective tissue disease of unknown etiology. Therapeutic options include high-dose corticosteroids and other immunosuppressive drugs. We present a typical eosinophilic fasciitis case, which did not respond to first-line treatment, but improved remarkably after infliximab administration. This report demonstrates that in case of initial treatment failure, infliximab might be a relatively safe and effective way of eosinophilic fasciitis management.

scholarly journals AB0543 CLINICAL CHARACTERISTICS OF A GROUP OF CHRONIC GRAFT-VERSUS-HOST DISEASE PATIENTS WITH POSITIVE AUTOIMMUNITY.

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1568.1-1568
Author(s):  
M. E. Acosta ◽  
L. Gómez-Lechón ◽  
O. Compán ◽  
S. Pastor ◽  
C. A. Montilla-Morales ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Clinical Characteristics ◽  
De Novo ◽  
Small Sample Size ◽  
Small Sample ◽  
Eosinophilic Fasciitis ◽  
Ocular Involvement ◽  
Host Disease ◽  
Graft Versus Host ◽  
Multidisciplinary Consultation

Background:Graft-versus-host disease (GVHD) is a commonly severe multiorgan complication in patients undergoing allogeneic transplantation of hematopoietic progenitors. Its chronic form reflects a complex immune response with different degrees of inflammation, immune dysregulation and fibrosis. In some chronic graft-versus-host disease (cGVHD) patients, positive antibodies have been detected, which represent the presence of immune activity and suggest the possible involvement of B lymphocytes in the disease etiopathogenesis, but their clinical utility is controversial.Objectives:To describe the clinical characteristics of a group of cGVHD patients with positive autoimmunity treated in a multidisciplinary consultation of Rheumatology-Dermatology- Hematology of GVHD.Methods:Observational and retrospective study to describe the clinical characteristics of the patients with positive autoimmunity collected in the database of the multidisciplinary consultation of GVHD. The variables reviewed for this study, in addition to the demographic ones, were type of antibody, disease causing the transplant, presentation, severity and type of involvement. The statistical analysis was done with Epi-info 7.2.2.6.Results:Only 16 (16%) of the 100 patients included in the database had positive autoimmunity. Twelve (75%) tested positive to ANA, although 5 (31.25%) in a lower titer (1/80). The most common immunofluorescence pattern was the nucleolar in 88.89% (66.67% nucleolar and 22.22% nucleolar + cytoplasmic). Other antibodies detected were: 6 anti-Ro52, 2 anti-dsDNA, 1 anti-RP155, 1 anti-Fibrillarin, 1 anti-SAE1, 1 p-ANCA and 1 anti-NOR-90. The mean of age was 51.31±14.03 years. As for sex 4 (25%) were female and 12 (75%) were men. The most frequent disease that caused the transplant was acute myeloid leukemia (58.3%). Ten (62.5%) patients presented de novo cGVHD, 1 (6.25%) progressive and 5 (31.25%) quiescent. The time since receiving the transplant until the first visit was 14 to 79 months. Ten (62.5%) patients had nonspecific symptoms (arthralgia and myalgia), 2 (12.5%) edema, 8 (50%) contractures, 8 (50%) fasciitis and 6 (37.5%) eosinophilia. Eight (50%) patients had ocular involvement and 6 (37.5%) of the oral mucosa in the form of dry syndrome (Sjögren-like syndrome). Ten (62.5%) patients had limitation of joint mobility detected by the range of motion scale (ROM), of which 6 were mild and 4 moderate. Only 5 (31.25%) patients had general condition impairment. As for the skin involvement 10 (62.5%) patients had sclerodermiform involvement (8 of them being eosinophilic fasciitis- like), 2 (12.5%) lichenoid, and 3 (18.5%) mixed (sclerodermiform + lichenoid). Only 1 patient didn´t meet diagnostic criteria for GVHD. The sclerodermiform was the most common type of involvement in the positive ANA patients. Regarding the severity according to the of the American National Institute of Health (NIH) classification: 8 (50%) had serious affectation, 5 (31.25%) moderate and 2 (12.5%) mild, with 4 (25%) exitus.Conclusion:In our cohort of patients with cGVHD, serum detection of autoantibodies is uncommon, being the ANA with nucleolar pattern the most frequent. Although the small sample size does not allow correlations with the clinical variables it´s worth highlighting a greater positivity of autoantibodies in the sclerodermiform skin forms.References:[1]Kuzmina Z et al. Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria. Am J Hematol. 2015 February; 90(2): 114–119.[2]Rhoades R, Gaballa S. The Role of B Cell Targeting in Chronic Graft-Versus-Host Disease, Biomedicines 2017, 5, 61: 2-10Disclosure of Interests:Maria Elisa Acosta: None declared, Luis Gómez-Lechón: None declared, Olga Compán: None declared, Sonia Pastor: None declared, Carlos A. Montilla-Morales: None declared, Olga Martínez González: None declared, Ana Isabel Turrión: None declared, Javier del Pino Grant/research support from: Roche, Bristol, Consultant of: Gedeon, Cristina Hidalgo: None declared

scholarly journals Groove Sign in Eosinophilic Fasciitis

2021 ◽  
Vol 96 (8) ◽  
pp. 2184
Author(s):  
Ahmed I. Mourad ◽  
Julia S. Lehman ◽  
P. Régine Mydlarski
Keyword(s):  
Eosinophilic Fasciitis

Imatinib as a potentially effective therapeutic alternative in corticosteroid‐resistant eosinophilic fasciitis

2020 ◽  
Vol 37 (6) ◽  
pp. 1171-1172
Author(s):  
Tiffany T. Wu ◽  
Heidi Goodarzi ◽  
Jennifer Wang ◽  
Roberto Novoa ◽  
Joyce M. C. Teng
Keyword(s):  
Eosinophilic Fasciitis ◽  
Therapeutic Alternative

Association Of Eosinophilic Fasciitis With Morphea

Folia Medica ◽  
2014 ◽  
Vol 56 (3) ◽  
Author(s):  
Lilia G. Zisova ◽  
Cvetana I. Abadjieva ◽  
Elena V. Obreshkova ◽  
Georgi K. Chernev ◽  
Nina I. Vutova
Keyword(s):  
Eosinophilic Fasciitis

The use of an elevated aldolase in diagnosing and managing eosinophilic fasciitis

2014 ◽  
Vol 34 (8) ◽  
pp. 1481-1484 ◽  
Author(s):  
Jennifer Nashel ◽  
Virginia Steen
Keyword(s):  
Eosinophilic Fasciitis

Th1- and Th17-polarized immune infiltrates in eosinophilic fasciitis-A potential marker for histopathologic distinction from morphea

2017 ◽  
Vol 44 (6) ◽  
pp. 548-552 ◽  
Author(s):  
Andrea Primiani Moy ◽  
Elena Maryamchik ◽  
Olga V. Nikolskaia ◽  
Rosalynn M. Nazarian
Keyword(s):  
Eosinophilic Fasciitis ◽  
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