Basis of Therapeutic Nuclear Medicine

2014 ◽  
pp. 313-328
Author(s):  
Abdelhamid H. Elgazzar
Keyword(s):  
Nuclear Medicine ◽  
Therapeutic Nuclear Medicine

Chelators and metal complex stability for radiopharmaceutical applications

2019 ◽  
Vol 107 (9-11) ◽  
pp. 1087-1120 ◽  
Author(s):  
Nkemakonam C. Okoye ◽  
Jakob E. Baumeister ◽  
Firouzeh Najafi Khosroshahi ◽  
Heather M. Hennkens ◽  
Silvia S. Jurisson
Keyword(s):  
Nuclear Medicine ◽  
Metal Complex ◽  
Complex Stability ◽  
Critical Aspect ◽  
Technetium 99M ◽  
Diagnostic Nuclear Medicine ◽  
Key Factor ◽  
The 1960S ◽  
Therapeutic Nuclear Medicine

Abstract Diagnostic and therapeutic nuclear medicine relies heavily on radiometal nuclides. The most widely used and well-known radionuclide is technetium-99m (99mTc), which has dominated diagnostic nuclear medicine since the advent of the 99Mo/99mTc generator in the 1960s. Since that time, many more radiometals have been developed and incorporated into potential radiopharmaceuticals. One critical aspect of radiometal-containing radiopharmaceuticals is their stability under in vivo conditions. The chelator that is coordinated to the radiometal is a key factor in determining radiometal complex stability. The chelators that have shown the most promise and are under investigation in the development of diagnostic and therapeutic radiopharmaceuticals over the last 5 years are discussed in this review.

Voxeldose: A Computer Program for 3-D Dose Calculation in Therapeutic Nuclear Medicine

2003 ◽  
Vol 18 (1) ◽  
pp. 109-115 ◽  
Author(s):  
Isabelle Gardin ◽  
Lionel G. Bouchet ◽  
Karine Assié ◽  
Jerome Caron ◽  
Albert Lisbona ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Computer Program ◽  
Dose Calculation ◽  
Therapeutic Nuclear Medicine

scholarly journals Therapeutic Radiometals: Worldwide Scientific Literature Trend Analysis (2008–2018)

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 640 ◽  
Author(s):  
Licia Uccelli ◽  
Petra Martini ◽  
Corrado Cittanti ◽  
Aldo Carnevale ◽  
Loretta Missiroli ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Trend Analysis ◽  
Scientific Literature ◽  
Research Output ◽  
Time Frame ◽  
Research Field ◽  
Literature Analysis ◽  
Global Trends ◽  
Interdisciplinary Nature ◽  
Therapeutic Nuclear Medicine

Academic journals have published a large number of papers in the therapeutic nuclear medicine (NM) research field in the last 10 years. Despite this, a literature analysis has never before been made to point out the research interest in therapeutic radionuclides (RNs). For this reason, the present study aims specifically to analyze the research output on therapeutic radiometals from 2008 to 2018, with intent to quantify and identify global trends in scientific literature and emphasize the interdisciplinary nature of this research field. The data search targeted conventional (131I, 90Y, 177Lu, 188Re, 186Re, 153Sm, 89Sr, 186Er) and emergent (67Cu, 47Sc, 223Ra, 166Ho, 161Tb, 149Tb, 212Pb/212Bi, 225Ac, 213Bi, 211At, 117mSn) RNs. Starting from this time frame, authors have analyzed and interpreted this scientific trend quantitatively first, and qualitatively after.

Dosimetry of Radiopharmaceuticals for Diagnostic and Therapeutic Nuclear Medicine

2011 ◽  
Author(s):  
Richard Smart ◽  
Anatoly Rosenfeld ◽  
Tomas Kron ◽  
Francesco d’Errico ◽  
Marko Moscovitch
Keyword(s):  
Nuclear Medicine ◽  
Therapeutic Nuclear Medicine
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