Imputation of Quantitative Genetic Interactions in Epistatic MAPs by Interaction Propagation Matrix Completion

2014 ◽  
pp. 448-462
Author(s):  
Marinka Žitnik ◽  
Blaž Zupan
Keyword(s):  
Matrix Completion ◽  
Genetic Interactions ◽  
Quantitative Genetic ◽  
Propagation Matrix

scholarly journals Quantitative Genetic Interactions Reveal Biological Modularity

Cell ◽  
2010 ◽  
Vol 141 (5) ◽  
pp. 739-745 ◽  
Author(s):  
Pedro Beltrao ◽  
Gerard Cagney ◽  
Nevan J. Krogan
Keyword(s):  
Genetic Interactions ◽  
Quantitative Genetic

scholarly journals Predicting Quantitative Genetic Interactions by Means of Sequential Matrix Approximation

PLoS ONE ◽  
2008 ◽  
Vol 3 (9) ◽  
pp. e3284 ◽  
Author(s):  
Aki P. Järvinen ◽  
Jukka Hiissa ◽  
Laura L. Elo ◽  
Tero Aittokallio
Keyword(s):  
Genetic Interactions ◽  
Matrix Approximation ◽  
Quantitative Genetic

scholarly journals Imputing and Predicting Quantitative Genetic Interactions in Epistatic MAPs

2011 ◽  
pp. 353-361 ◽  
Author(s):  
Colm Ryan ◽  
Gerard Cagney ◽  
Nevan Krogan ◽  
Pádraig Cunningham ◽  
Derek Greene
Keyword(s):  
Genetic Interactions ◽  
Quantitative Genetic

scholarly journals Towards accurate imputation of quantitative genetic interactions

2009 ◽  
Vol 10 (12) ◽  
pp. R140 ◽  
Author(s):  
Igor Ulitsky ◽  
Nevan J Krogan ◽  
Ron Shamir
Keyword(s):  
Genetic Interactions ◽  
Quantitative Genetic

scholarly journals Multiplexed quantitative screens of single cell shape and YAP/TAZ localisation identify DOCK5 as a coincident detector of polarity and adhesion during migration

2020 ◽  
Author(s):  
Patricia Pascual-Vargas ◽  
Mar Arias-Garcia ◽  
Theodoros I. Roumeliotis ◽  
Jyoti S. Choudhary ◽  
Chris Bakal
Keyword(s):  
Breast Cancer ◽  
Focal Adhesion ◽  
Cell Shape ◽  
Triple Negative ◽  
Leading Edge ◽  
Genetic Interactions ◽  
Genetic Screens ◽  
Protein Levels ◽  
Quantitative Genetic ◽  
Metastatic Cells

AbstractYAP and TAZ are transcriptional co-activators that are often constitutively active in triple negative breast cancer (TNBC) cells driving proliferation, invasion, and drug resistance. Through multiplexed quantitative genetic screens for YAP/TAZ localisation and cell shape, we found that the RhoGEF DOCK5 is essential for YAP/TAZ activation in metastatic cells and is required for the maintenance of polarity during migration. DOCK5 regulates cell shape and thus YAP/TAZ through different genetic interactions with CDC42, RAC, and RHOA GTPases. DOCK5 regulates focal adhesion (FA) morphogenesis in RAC-dependent fashions that promote RHOA mediated actomyosin engagement of FA. Using unbiased systems-level quantification of protein levels by mass spectrometry we show that DOCK5 maintains polarity by stabilising protein levels of the CDC42 effector GSK3β. We conclude DOCK5 acts as a coincidence detector to promote leading edge persistence in subcellular locations where there is both RAC and RHOA dependent FA morphogenesis and active CDC42 mediated cell polarisation.

scholarly journals From E‐MAPs to module maps: dissecting quantitative genetic interactions using physical interactions

2008 ◽  
Vol 4 (1) ◽  
pp. 209 ◽  
Author(s):  
Igor Ulitsky ◽  
Tomer Shlomi ◽  
Martin Kupiec ◽  
Ron Shamir
Keyword(s):  
Genetic Interactions ◽  
Quantitative Genetic ◽  
Physical Interactions

Distant Supervision for Relation Extraction with Matrix Completion

2014 ◽  
Author(s):  
Miao Fan ◽  
Deli Zhao ◽  
Qiang Zhou ◽  
Zhiyuan Liu ◽  
Thomas Fang Zheng ◽  
...  
Keyword(s):  
Matrix Completion ◽  
Relation Extraction ◽  
Distant Supervision
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