scholarly journals Safety Validation of Sense and Avoid Algorithms Using Simulation and Evolutionary Search

Author(s):  
Xueyi Zou ◽  
Rob Alexander ◽  
John McDermid
Author(s):  
Kyle Foerster ◽  
Michael Mullins ◽  
Naima Kaabouch ◽  
William Semke

2021 ◽  
Author(s):  
Tanya Glozman ◽  
Anthony Narkawicz ◽  
Ishay Kamon ◽  
Franco Callari ◽  
Amir Navot
Keyword(s):  

2018 ◽  
Author(s):  
David Ascough ◽  
Fernanda Duarte ◽  
Robert Paton

The base-catalyzed rearrangement of arylindenols is a rare example of a suprafacial [1,3]-hydrogen atom transfer. The mechanism has been proposed to proceed via sequential [1,5]-sigmatropic shifts, which occur in a selective sense and avoid an achiral intermediate. A computational analysis using quantum chemistry casts serious doubt on these suggestions: these pathways have enormous activation barriers and in constrast to what is observed experimentally, they overwhelmingly favor a racemic product. Instead we propose that a suprafacial [1,3]-prototopic shift occurs in a two-step deprotonation/reprotonation sequence. This mechanism is favored by 15 kcal mol<sup>-1</sup> over that previously proposed. Most importantly, this is also consistent with stereospecificity since reprotonation occurs rapidly on the same p-face. We have used explicitly-solvated molecular dynamics studies to study the persistence and condensed-phase dynamics of the intermediate ion-pair formed in this reaction. Chirality transfer is the result of a particularly resilient contact ion-pair, held together by electrostatic attraction and a critical NH···p interaction which ensures that this species has an appreciable lifetime even in polar solvents such as DMSO and MeOH.


2017 ◽  
Vol 11 (5) ◽  
pp. 571-580 ◽  
Author(s):  
Zhouyu Zhang ◽  
Yunfeng Cao ◽  
Meng Ding ◽  
Likui Zhuang ◽  
Weiwen Yao ◽  
...  

Author(s):  
Gregory E. Coxson ◽  
Jon C. Russo ◽  
Angeline Luther

2021 ◽  
Vol 26 (4) ◽  
Author(s):  
Man Zhang ◽  
Bogdan Marculescu ◽  
Andrea Arcuri

AbstractNowadays, RESTful web services are widely used for building enterprise applications. REST is not a protocol, but rather it defines a set of guidelines on how to design APIs to access and manipulate resources using HTTP over a network. In this paper, we propose an enhanced search-based method for automated system test generation for RESTful web services, by exploiting domain knowledge on the handling of HTTP resources. The proposed techniques use domain knowledge specific to RESTful web services and a set of effective templates to structure test actions (i.e., ordered sequences of HTTP calls) within an individual in the evolutionary search. The action templates are developed based on the semantics of HTTP methods and are used to manipulate the web services’ resources. In addition, we propose five novel sampling strategies with four sampling methods (i.e., resource-based sampling) for the test cases that can use one or more of these templates. The strategies are further supported with a set of new, specialized mutation operators (i.e., resource-based mutation) in the evolutionary search that take into account the use of these resources in the generated test cases. Moreover, we propose a novel dependency handling to detect possible dependencies among the resources in the tested applications. The resource-based sampling and mutations are then enhanced by exploiting the information of these detected dependencies. To evaluate our approach, we implemented it as an extension to the EvoMaster tool, and conducted an empirical study with two selected baselines on 7 open-source and 12 synthetic RESTful web services. Results show that our novel resource-based approach with dependency handling obtains a significant improvement in performance over the baselines, e.g., up to + 130.7% relative improvement (growing from + 27.9% to + 64.3%) on line coverage.


2020 ◽  
Vol 53 (2) ◽  
pp. 14742-14747
Author(s):  
Zhouyu Zhang ◽  
Youmin Zhang ◽  
Yunfeng Cao ◽  
Meng Ding
Keyword(s):  

2016 ◽  
Vol 55 ◽  
pp. 344-358 ◽  
Author(s):  
Subramanian Ramasamy ◽  
Roberto Sabatini ◽  
Alessandro Gardi ◽  
Jing Liu

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