Glucagon Stimulation Test for GHD (GST)

Abstract Background Glucagon stimulation test (GST) is often employed to assess the insulin reserve of the pancreatic beta cells in diabetic subjects. The clinical significance of the increment of plasma glucose (Δglucose) by exogenous glucagon during GST has not been elucidated. We investigated the relationship between Δglucose and clinical parameters including the liver and renal function in type 2 diabetic subjects, since we hypothesized that Δglucose is associated with the liver and renal function reflecting the capacity for gluconeogenesis in the organs. Methods A total of 209 subjects with type 2 diabetes who underwent GST during admission were included in this cross-sectional study. We defined the difference between plasma glucose at fasting and 6 min after intravenous injection of 1 mg glucagon as Δglucose. We assessed correlations between Δglucose and clinical parameters such as diabetic duration, BMI, HbA1c, beta cell function, serum free fatty acids (FFA) which is known to stimulate gluconeogenesis, liver function, the indices of liver function, renal function, and urinary albumin excretion (UAE). Results In correlation analysis, Δglucose positively correlated to FFA and estimated glomerular filtration rate (eGFR), but inversely to serum creatinine and cystatin C, although Δglucose showed no correlation with both liver function and the indices of residual liver function. Multiple regression analysis revealed that Δglucose was an independent determinant for the eGFR after 1 year, equally BMI, HbA1c, serum lipids, and UAE, which are known as the predictors for the development of chronic kidney disease. Conclusion Our results suggest that Δglucose during GST might be related to gluconeogenesis in the kidney and could be the determinant of future renal function in type 2 diabetes.

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Repeatability of C-peptide response in glucagon stimulation test

Acta Endocrinologica ◽

10.1530/acta.0.1140515 ◽

1987 ◽

Vol 114 (4) ◽

pp. 515-518 ◽

Cited By ~ 5

Author(s):

H. Sarlund ◽

O. Siitonen ◽

M. Laakso ◽

K. Pyörälä

Keyword(s):

Stimulation Test ◽

Oral Drugs ◽

Glucagon Stimulation Test ◽

C Peptide ◽

Peptide Level ◽

Before And After ◽

Insulin Dependent

Abstract. Measurement of the plasma C-peptide level before and after iv administration of 1 mg of glucagon was repeated four times in 10 elderly non-diabetic subjects and in 20 elderly non-insulin-dependent diabetics treated with diet or oral drugs to assess the repeatability of the C-peptide responses. Plasma C-peptide levels before and after glucagon administration and C-peptide glucose ratios in the four measurements did not differ significantly from test to test either in diabetic or non-diabetic subjects. The results of the present study indicate that the repeatability of C-peptide response to glucagon is very good both in non-insulin-dependent diabetics and in non-diabetic subjects.

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Glucagon stimulation test: assessment of β-cell function in gestational diabetes mellitus

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/0028-2243(94)90149-x ◽

1994 ◽

Vol 56 (1) ◽

pp. 27-30 ◽

Cited By ~ 5

Author(s):

M.L. Jacobs ◽

S. Verhoog ◽

W.-H. van der Linden ◽

W.M. Huisman ◽

H.C.S. Wallenburg ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Cell Function ◽

Stimulation Test ◽

Glucagon Stimulation Test ◽

Β Cell ◽

Test Assessment ◽

Β Cell Function

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Short-term glucagon stimulation test of C-peptide effect on glucose utilization in patients with type 1 diabetes mellitus

Medical & Biological Engineering & Computing ◽

10.1007/s11517-015-1416-2 ◽

2015 ◽

Vol 53 (12) ◽

pp. 1361-1369 ◽

Cited By ~ 1

Author(s):

Viliam Mojto ◽

Zuzana Rausova ◽

Jana Chrenova ◽

Ladislav Dedik

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Glucose Utilization ◽

Stimulation Test ◽

Glucagon Stimulation Test ◽

Short Term ◽

C Peptide

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Pegvisomant-primed glucagon stimulation test in assessing GH reserve and GH/IGF kinetics in adults suspected of GH deficiency

Pituitary ◽

10.1007/s11102-015-0688-8 ◽

2015 ◽

Vol 19 (1) ◽

pp. 65-74 ◽

Cited By ~ 3

Author(s):

Kevin C. J. Yuen ◽

Jan Frystyk ◽

Sharon A. Rhoads ◽

Martin Bidlingmaier

Keyword(s):

Gh Deficiency ◽

Stimulation Test ◽

Glucagon Stimulation Test

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