A Novel Cysteine Sulfinic Acid Decarboxylase Knock-Out Mouse: Immune Function

2015 ◽  
pp. 89-98 ◽  
Author(s):  
Seung Yong Park ◽  
Georgia Schuller-Levis ◽  
Eunkyue Park
Keyword(s):  
Immune Function ◽  
Acid Decarboxylase ◽  
Sulfinic Acid ◽  
Cysteine Sulfinic Acid ◽  
Knock Out ◽  
Cysteine Sulfinic Acid Decarboxylase ◽  
Knock Out Mouse

Cloning and characterization of rat cysteine sulfinic acid decarboxylase

1995 ◽  
Vol 1262 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Pamela J. Kaisakia ◽  
Ann A. Jerkins ◽  
David C. Goodspeed ◽  
Robert D. Steele
Keyword(s):  
Acid Decarboxylase ◽  
Sulfinic Acid ◽  
Cysteine Sulfinic Acid ◽  
Cysteine Sulfinic Acid Decarboxylase

Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA expression in murine tissues

2002 ◽  
Vol 1574 (3) ◽  
pp. 403-406 ◽  
Author(s):  
Eunkyue Park ◽  
Seung Yong Park ◽  
Chuanhua Wang ◽  
Jiliu Xu ◽  
Giuseppe LaFauci ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Acid Decarboxylase ◽  
Sulfinic Acid ◽  
Cysteine Sulfinic Acid ◽  
Cysteine Sulfinic Acid Decarboxylase

scholarly journals Analysis of Antibody Reactivity against Cysteine Sulfinic Acid Decarboxylase, A Pyridoxal Phosphate-Dependent Enzyme, in Endocrine Autoimmune Disease

2004 ◽  
Vol 89 (4) ◽  
pp. 1636-1640 ◽  
Author(s):  
Filip Sköldberg ◽  
Fredrik Rorsman ◽  
Jaakko Perheentupa ◽  
Mona Landin-Olsson ◽  
Eystein S. Husebye ◽  
...  
Keyword(s):  
Amino Acid ◽  
Autoimmune Disease ◽  
Pyridoxal Phosphate ◽  
Acid Decarboxylase ◽  
Endocrine Disorders ◽  
Sulfinic Acid ◽  
Cysteine Sulfinic Acid ◽  
Gad 65 ◽  
Cysteine Sulfinic Acid Decarboxylase ◽  
Group Ii

Abstract The structurally related group II pyridoxal phosphate (PLP)-dependent amino acid decarboxylases glutamic acid decarboxylase (GAD), aromatic l-amino acid decarboxylase (AADC), and histidine decarboxylase (HDC) are known autoantigens in endocrine disorders. We report, for the first time, the prevalence of serum autoantibody reactivity against cysteine sulfinic acid decarboxylase (CSAD), an enzyme that shares 50% amino acid identity with the 65- and 67-kDa isoforms of GAD (GAD-65 and GAD-67), in endocrine autoimmune disease. Three of 83 patients (3.6%) with autoimmune polyendocrine syndrome type 1 (APS1) were anti-CSAD positive in a radioimmunoprecipitation assay. Anti-CSAD antibodies cross-reacted with GAD-65, and the anti-CSAD-positive sera were also reactive with AADC and HDC. The low frequency of anti-CSAD reactivity is in striking contrast to the prevalence of antibodies against GAD-65, AADC, and HDC in APS1 patients, suggesting that different mechanisms control the immunological tolerance toward CSAD and the other group II decarboxylases. Moreover, CSAD may be a useful mold for the construction of recombinant chimerical antigens in attempts to map conformational epitopes on other group II PLP-dependent amino acid decarboxylases.

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