Syndromes of Resistance to Thyroid Hormone Action

2015 ◽  
pp. 95-112 ◽  
Author(s):  
Luca Persani ◽  
Irene Campi ◽  
Federica Marelli
Keyword(s):  
Thyroid Hormone ◽  
Hormone Action ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Action

scholarly journals Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance

2021 ◽  
Author(s):  
Marcus Heldmann ◽  
Krishna Chatterjee ◽  
Carla Moran ◽  
Berenike Rogge ◽  
Julia Steinhardt ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Pituitary Gland ◽  
Hormone Receptors ◽  
Thyroid Hormone Receptor ◽  
Magnetic Resonance Images ◽  
Healthy Controls ◽  
Hormone Action ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Action ◽  
Thyroid Hormone Receptor Β

Background: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α,β) with differential tissue distribution. Thyroid hormone receptor β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly expressing the β form of the receptor (pituitary, liver). This study seeks to identify effects of mutant TRβ on pituitary size. Methods: High-resolution 3D T1-weighted magnetic resonance images were acquired in 19 patients with RTHβ in comparison to 19 healthy matched controls. Volumetric measurements of the pituitary gland were performed independently and blinded by four different raters (two neuroradiologists, one neurologist, one neuroscientist). Results: Patients with mutant TRβ (Resistance to Thyroid Hormone β,RΤΗβ) showed elevated fT3/4 levels with normal TSH levels, whereas healthy controls showed normal thyroid hormone levels. Imaging revealed smaller pituitary size in RTHβ patients in comparison to healthy controls (F(1,35)=7.05, p=0.012, partial η2 =0.17). Conclusion: RTHβ subjects have impaired sensitivity to thyroid hormones, along with decreased size of the pituitary gland.

Peripheral Parameters of Thyroid Hormone Action in Resistance to Thyroid Hormone Syndrome: A Focus on Mineral Metabolism

Thyroid ◽  
2009 ◽  
Vol 19 (7) ◽  
pp. 785-787 ◽  
Author(s):  
Gustavo Leopoldo Rodrigues Dare ◽  
Patrícia Künzle Ribeiro Magalhaes ◽  
Margaret de Castro ◽  
Lea Maria Zanini Maciel
Keyword(s):  
Thyroid Hormone ◽  
Mineral Metabolism ◽  
Hormone Action ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Action

Age-Related Resistance to Thyroid Hormone Action

Drugs & Aging ◽  
2019 ◽  
Vol 36 (11) ◽  
pp. 1007-1014
Author(s):  
Arshag D. Mooradian
Keyword(s):  
Thyroid Hormone ◽  
Hormone Action ◽  
Resistance To Thyroid Hormone ◽  
Thyroid Hormone Action ◽  
Age Related
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