The Role of Schwann Cells in Peripheral Nerve Function, Injury, and Repair

2020 ◽  
pp. 1-22
Author(s):  
Christina M. A. P. Schuh ◽  
Ana Maria Sandoval-Castellanos ◽  
Cristian De Gregorio ◽  
Pamina Contreras-Kallens ◽  
John W. Haycock
Keyword(s):  
Peripheral Nerve ◽  
Schwann Cells ◽  
Nerve Function ◽  
Peripheral Nerve Function ◽  
Injury And Repair

The Role of Schwann Cells in Peripheral Nerve Function, Injury, and Repair

2020 ◽  
pp. 215-236
Author(s):  
Christina M. A. P. Schuh ◽  
Ana Maria Sandoval-Castellanos ◽  
Cristian De Gregorio ◽  
Pamina Contreras-Kallens ◽  
John W. Haycock
Keyword(s):  
Peripheral Nerve ◽  
Schwann Cells ◽  
Nerve Function ◽  
Peripheral Nerve Function ◽  
Injury And Repair

Diseases of the peripheral nerves

2010 ◽  
pp. 5076-5095
Author(s):  
R.D.M. Hadden ◽  
P.K. Thomas ◽  
R.A.C. Hughes
Keyword(s):  
Peripheral Nerve ◽  
Schwann Cells ◽  
Cell Body ◽  
Case History ◽  
Nerve Function ◽  
Muscular Weakness ◽  
Neuron Cell Body ◽  
Peripheral Nerve Function ◽  
Demyelinating Neuropathies ◽  
Amyloid P

Case History—A 34 yr old man presenting with jaundice, lymphadenopathy, sensory symptoms and muscular weakness. Disorders of peripheral nerve function can be categorized in terms of the site of the primary disturbance. (1) Neuronopathies—conditions that lead to death of the neuron cell body and axon. (2) Axonal neuropathies—conditions that affect axons which may be focal, as in local injury, multifocal, as in vasculitis, or diffuse as in metabolic or toxic disorders often cause selective degeneration of the axons towards the cell bodies (‘dying-back’); (3) Demyelinating neuropathies—conditions in which the myelin sheaths are supporting Schwann cells damaged and the axons are relatively preserved. Combinations of axonal and demyelinating pathology are common. (4) Interstitial neuropathies—conditions in which there is infiltration of the endoneurium for instance by granuloma or amyloid....

Role of metallothioneins in peripheral nerve function and regeneration

2003 ◽  
Vol 60 (6) ◽  
pp. 1209-1216 ◽  
Author(s):  
D. Ceballos ◽  
N. Lago ◽  
E. Verdú ◽  
M. Penkowa ◽  
J. Carrasco ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Function ◽  
Peripheral Nerve Function

Role of Peripheral Nerve-Derived Fibroblasts and Schwann Cells in CD40/CD40L and CD80/CD86-Mediated Rejection

2006 ◽  
Vol 22 (06) ◽  
Author(s):  
Deborah Yu ◽  
Sherri Wood ◽  
Keri Smith ◽  
Keith Bishop ◽  
Paul Cederna
Keyword(s):  
Peripheral Nerve ◽  
Schwann Cells

scholarly journals Chemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jana Müller ◽  
Charlotte Kreutz ◽  
Steffen Ringhof ◽  
Maximilian Koeppel ◽  
Nikolaus Kleindienst ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Peripheral Nerve ◽  
Postural Control ◽  
Action Potentials ◽  
Exercise Intervention ◽  
Cross Sectional Study ◽  
Nerve Function ◽  
Cross Sectional ◽  
Peripheral Nerve Function

AbstractImpaired postural control is often observed in response to neurotoxic chemotherapy. However, potential explanatory factors other than chemotherapy-induced peripheral neuropathy (CIPN) have not been adequately considered to date due to primarily cross-sectional study designs. Our objective was to comprehensively analyze postural control during and after neurotoxic chemotherapy, and to identify potential CIPN-independent predictors for its impairment. Postural control and CIPN symptoms (EORTC QLQ-CIPN20) were longitudinally assessed before, during and three weeks after neurotoxic chemotherapy, and in three and six months follow-up examinations (N = 54). The influence of peripheral nerve function as determined by nerve conduction studies (NCS: compound motor action potentials (CMAP) and sensory action potentials (SNAP)), physical activity, and muscle strength on the change in postural control during and after chemotherapy was analyzed by multiple linear regression adjusted for age and body mass index. Postural control, CIPN signs/symptoms, and CMAP/SNAP amplitudes significantly deteriorated during chemotherapy (p < .01). During follow-up, patients recovered from postural instabilities (p < .01), whereas CIPN signs/symptoms and pathologic NCS findings persisted compared to baseline (p < .001). The regression model showed that low CMAP and high SNAP amplitudes at baseline predicted impairment of postural control during but not after chemotherapy. Hence, pre-therapeutically disturbed somatosensory inputs may induce adaptive processes that have compensatory effects and allow recovery of postural control while CIPN signs/symptoms and pathologic peripheral nerve function persist. Baseline NCS findings in cancer patients who receive neurotoxic chemotherapy thus might assist in delineating individual CIPN risk profiles more precisely to which specific exercise intervention programs could be tailor-made.

Peripheral nerve function in patients with familial amyloid polyneuropathy after liver transplantation

Amyloid ◽  
2003 ◽  
Vol 10 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Sachio Kobayashi ◽  
Hiroshi Morita ◽  
Teruko Asawa ◽  
Yo-Ichi Takei ◽  
Takao Hashimoto ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Peripheral Nerve ◽  
Familial Amyloid Polyneuropathy ◽  
Nerve Function ◽  
Amyloid Polyneuropathy ◽  
Peripheral Nerve Function
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