Design and Development of a Highly Macroporous Silicone Scaffold as a Bioartificial Pancreas for Type 1 Diabetes

2009 ◽  
pp. 233-234
Author(s):  
E. Pedraza ◽  
C. Fraker ◽  
A. C. Brady ◽  
C. Stabler
Keyword(s):  
Type 1 Diabetes ◽  
Bioartificial Pancreas ◽  
Design And Development

scholarly journals Optimization of An O2-Balanced Bioartificial Pancreas for Type 1 Diabetes Using Statistical Design of Experiment.

2021 ◽  
Author(s):  
Anne Mouré ◽  
Sawsen Bekir ◽  
Elodie Bacou ◽  
Karine Haurogne ◽  
Marie Allard ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Design Of Experiment ◽  
Statistical Design ◽  
Bioartificial Pancreas ◽  
Promising Alternative ◽  
Neonatal Pig ◽  
And Function ◽  
Full Factorial

Abstract A bioArtificial pancreas (BAP) encapsulating high pancreatic islets concentration is a promising alternative for type 1 diabetes. However, the main limitation of this approach is O2 supply, especially until graft neovascularization. Here, we described a methodology to design an optimal O2-balanced BAP using statistical design of experiment (DoE). A full factorial DoE was first performed to screen two O2-technologies on their ability to preserve pseudo-islet viability and function under hypoxia and normoxia. Then, response surface methodology was used to define the optimal O2-carrier and islet seeding concentrations to maximize the number of viable pseudo-islets in the BAP containing an O2-generator under hypoxia. Monitoring of viability, function and maturation of neonatal pig islets for 15 days in vitro demonstrated the efficiency of the optimal O2-balanced BAP. The findings should allow the design of a more realistic BAP for humans with high islets concentration by maintaining the O2 balance in the device.

scholarly journals Design and development of a stepped-care behavioral intervention to support parents of young children newly diagnosed with type 1 diabetes

2017 ◽  
Vol 62 ◽  
pp. 1-10 ◽  
Author(s):  
Marisa E. Hilliard ◽  
Carrie Tully ◽  
Maureen Monaghan ◽  
Jichuan Wang ◽  
Randi Streisand
Keyword(s):  
Type 1 Diabetes ◽  
Young Children ◽  
Behavioral Intervention ◽  
Stepped Care ◽  
Newly Diagnosed ◽  
Design And Development

Design and development of a scale measuring fear of complications in type 1 diabetes

2005 ◽  
Vol 21 (3) ◽  
pp. 264-270 ◽  
Author(s):  
Emily P. Taylor ◽  
John R. Crawford ◽  
Ann E. Gold
Keyword(s):  
Type 1 Diabetes ◽  
Design And Development

scholarly journals Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus

2018 ◽  
Vol 18 (7) ◽  
pp. 1735-1744 ◽  
Author(s):  
Per-Ola Carlsson ◽  
Daniel Espes ◽  
Amir Sedigh ◽  
Avi Rotem ◽  
Baruch Zimerman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Human Islets ◽  
Bioartificial Pancreas

scholarly journals Design and Development of a Context-Aware Knowledge-Based Module for Identifying Relevant Information and Information Gaps in Patients With Type 1 Diabetes Self-Collected Health Data

JMIR Diabetes ◽  
10.2196/10431 ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. e10431 ◽  
Author(s):  
Alain Giordanengo ◽  
Pinar Øzturk ◽  
Anne Helen Hansen ◽  
Eirik Årsand ◽  
Astrid Grøttland ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Relevant Information ◽  
Health Data ◽  
Context Aware ◽  
Design And Development ◽  
Knowledge Based ◽  
Information Gaps

Early Evidence of Atherosclerosis Seen in Teens With Type 1 Diabetes

2005 ◽  
Vol 39 (8) ◽  
pp. 2
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  
Type 1 Diabetes ◽  
Early Evidence

Girls With Type 1 Diabetes: Poor Insulin Control

2007 ◽  
Vol 41 (6) ◽  
pp. 5
Author(s):  
John R. Bell
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Control
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