High Wall Shear Stress Gradient Suppress Morphological Responses of Endothelial Cells to Fluid Flow

2009 ◽  
pp. 312-313 ◽  
Author(s):  
M. Sato ◽  
N. Saito ◽  
N. Sakamoto ◽  
T. Ohashi
Keyword(s):  
Endothelial Cells ◽  
Shear Stress ◽  
Fluid Flow ◽  
Wall Shear Stress ◽  
Stress Gradient ◽  
High Wall Shear Stress ◽  
Wall Shear Stress Gradient ◽  
Shear Stress Gradient ◽  
Morphological Responses ◽  
Wall Shear

Numerical Investigation and Prediction of Atherogenic Sites in Branching Arteries

1995 ◽  
Vol 117 (3) ◽  
pp. 350-357 ◽  
Author(s):  
M. Lei ◽  
C. Kleinstreuer ◽  
G. A. Truskey
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Blood Vessels ◽  
Vector Fields ◽  
Stress Gradient ◽  
Western World ◽  
Medium Size ◽  
Wall Shear Stress Gradient ◽  
Shear Stress Gradient ◽  
Wall Shear

Atherosclerosis, a disease of large- and medium-size arteries, is the chief cause of death in the US and most of the western world. It is widely accepted that the focal nature of the disease in arterial bends, junctions, and bifurcations is directly related to locally abnormal hemodynamics, often labeled “disturbed flows.” Employing the aorto-celiac junction of rabbits as a representative atherosclerotic model and considering other branching blood vessels with their distinctive input wave forms, it is suggested that the local wall shear stress gradient (WSSG) is the single best indicator of nonuniform flow fields leading to atherogenesis. Alternative predictors of susceptible sites are briefly evaluated. The results discussed include transient velocity vector fields, wall shear stress gradient distributions, and a new dimensionless parameter for the prediction of the probable sites of stenotic developments in branching blood vessels. Some of the possible underlying biological aspects of atherogenesis due to locally significant |WSSG|-magnitudes are briefly discussed.

scholarly journals Modulating wall shear stress gradient via equilateral triangular channel for in situ cellular adhesion assay

2016 ◽  
Vol 10 (5) ◽  
pp. 054119 ◽  
Author(s):  
Hyung Woo Kim ◽  
Seonjin Han ◽  
Wonkyoung Kim ◽  
Jiwon Lim ◽  
Dong Sung Kim
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Stress Gradient ◽  
Cellular Adhesion ◽  
Adhesion Assay ◽  
Triangular Channel ◽  
Wall Shear Stress Gradient ◽  
Shear Stress Gradient ◽  
Wall Shear

scholarly journals Hemodynamics of Cerebral Aneurysm Initiation: The Role of Wall Shear Stress and Spatial Wall Shear Stress Gradient

2011 ◽  
Vol 32 (3) ◽  
pp. 587-594 ◽  
Author(s):  
Z. Kulcsár ◽  
Á. Ugron ◽  
M. Marosfői ◽  
Z. Berentei ◽  
G. Paál ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Cerebral Aneurysm ◽  
Stress Gradient ◽  
Wall Shear Stress Gradient ◽  
Shear Stress Gradient ◽  
Wall Shear

scholarly journals Pulsatile Wall Shear Stress Gradient and Aortoseptal Angle: Implications for Subaortic Stenosis † 147

1997 ◽  
Vol 41 ◽  
pp. 27-27
Author(s):  
Michael D. VanAuker ◽  
Theresa A. Tacy ◽  
Gunnlaugur Sigfusson ◽  
Pedro J. Del Nido ◽  
Edward G. Cape
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Stress Gradient ◽  
Subaortic Stenosis ◽  
Wall Shear Stress Gradient ◽  
Shear Stress Gradient ◽  
Wall Shear

Wall shear stress gradient topography in the normal left coronary arterial tree: possible implications for atherogenesis

2004 ◽  
Vol 20 (5) ◽  
pp. 587-596 ◽  
Author(s):  
Thomas M. Farmakis ◽  
Johannes V. Soulis ◽  
George D. Giannoglou ◽  
George J. Zioupos ◽  
George E. Louridas
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Stress Gradient ◽  
Arterial Tree ◽  
Wall Shear Stress Gradient ◽  
Shear Stress Gradient ◽  
Wall Shear

Distinguishing endothelial responses to impingement force, wall shear stress, and wall shear stress gradient

2006 ◽  
Vol 39 ◽  
pp. S312
Author(s):  
E. Metaxa ◽  
J. Kolega ◽  
M.P. Szymanski ◽  
Z.J. Wang ◽  
D.D. Swartz ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Stress Gradient ◽  
Wall Shear Stress Gradient ◽  
Shear Stress Gradient ◽  
Wall Shear

High Wall Shear Stress and Positive Wall Shear Stress Gradient Trigger the Initiation of Intracranial Aneurysms

2009 ◽  
Author(s):  
Eleni Metaxa ◽  
Markus Tremmel ◽  
Jianping Xiang ◽  
John Kolega ◽  
Max Mandelbaum ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Intracranial Aneurysms ◽  
Potential Role ◽  
Stress Gradient ◽  
Local Flow ◽  
High Wall Shear Stress ◽  
Wall Shear Stress Gradient ◽  
Wall Shear

While the pathogenesis of an intracranial aneurysm (IA) is poorly understood, it has been generally postulated to be related to hemodynamic insult. IAs are predominantly located at apices of arterial bifurcations or outer curves on or near the Circle of Willis, suggesting a potential role of the specific hemodynamics at such locations characterized by high wall shear stress (WSS). Clinically, new IA formation has been observed following local flow increase.

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